The efficacy of Epigallocatechin-3-gallate (green tea) in the treatment of Alzheimer's disease: an overview of pre-clinical studies and translational perspectives in clinical practice.
The efficacy of Epigallocatechin-3-gallate (green tea) in the treatment of Alzheimer's disease: an overview of pre-clinical studies and translational perspectives in clinical practice.
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DOI：
10.1186/s13027-017-0145-6
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发表时间：
2017
影响因子：
3.7
通讯作者：
Cuomo A
中科院分区：
文献类型：
--
作者：
Cascella M;Bimonte S;Muzio MR;Schiavone V;Cuomo A
阿尔茨海默病（AD）是一种神经退行性疾病，也是最常见的痴呆症形式，其特征是认知和记忆障碍。氧化应激参与了AD的发生发展，是AD发病的机制之一。此外，多项研究证实，主要由人疱疹病毒1 （HHV-1）、巨细胞病毒（CMV）、人疱疹病毒2 （HHV-2）和丙型肝炎病毒（HCV）诱导的慢性病毒感染可能与AD的神经病理有关。尽管有大量关于阿尔茨海默病（AD）发病机制的数据，但迄今为止已经开发的治疗药物和/或药理学方法数量非常有限。值得强调的是，近年来，由于天然化合物具有抗氧化剂和抗炎特性，人们对其进行了大量研究，并将其确定为预防和治疗包括阿尔茨海默病在内的神经退行性疾病的有希望的药物。表没食子儿茶素和没食子酸的酯(−)-表没食子儿茶素-3-没食子酸酯（EGCG）是固体绿茶提取物中发现的主要和最显著的生物活性多酚。几项研究表明，该化合物具有重要的抗炎和抗动脉粥样硬化特性，以及对神经元损伤和脑水肿的保护作用。迄今为止，文献报道了许多关于EGCG在AD治疗中的潜在作用的研究。本文综述了EGCG在AD预防和治疗中的体外和体内临床前研究，并为临床应用提供新的见解。
Alzheimer’s disease (AD) is a neurodegenerative disorder and the most common form of dementia characterized by cognitive and memory impairment. One of the mechanism involved in the pathogenesis of AD, is the oxidative stress being involved in AD‘s development and progression. In addition, several studies proved that chronic viral infections, mainly induced by Human herpesvirus 1 (HHV-1), Cytomegalovirus (CMV), Human herpesvirus 2 (HHV-2), and Hepatitis C virus (HCV) could be responsible for AD’s neuropathology. Despite the large amount of data regarding the pathogenesis of Alzheimer’s disease (AD), a very limited number of therapeutic drugs and/or pharmacological approaches, have been developed so far. It is important to underline that, in recent years, natural compounds, due their antioxidants and anti-inflammatory properties have been largely studied and identified as promising agents for the prevention and treatment of neurodegenerative diseases, including AD. The ester of epigallocatechin and gallic acid, (−)-Epigallocatechin-3-Gallate (EGCG), is the main and most significantly bioactive polyphenol found in solid green tea extract. Several studies showed that this compound has important anti-inflammatory and antiatherogenic properties as well as protective effects against neuronal damage and brain edema. To date, many studies regarding the potential effects of EGCG in AD’s treatment have been reported in literature. The purpose of this review is to summarize the in vitro and in vivo pre-clinical studies on the use of EGCG in the prevention and the treatment of AD as well as to offer new insights for translational perspectives into clinical practice.