Emerging evidence for inflammation in conditions frequently affecting older adults: Report of a symposium
Emerging evidence for inflammation in conditions frequently affecting older adults: Report of a symposium
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DOI：
10.1111/j.1532-5415.1999.tb01299.x
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发表时间：
1999-08-01
影响因子：
6.3
通讯作者：
Silver, D
中科院分区：
文献类型：
--
作者：
Hamerman, D;Berman, JW;Silver, D
David Hamerman，MD，*Joan W.Berman，PhD，t Gregory W.Albers，MD，*David L.Brown，MD，§和David Silver，MDV Avid Hamerman，MD：随着个人年龄的增长，他们越来越多地受到导致死亡和发病率的疾病的影响。这次研讨会中讨论的情况特别具有代表性，即内科医生在接触越来越多的老年患者时观察到的情况，特别是“最年长的老年人”，范围从急性致命事件到伴有相关发病率的急性发作，再到仅仅是慢性。这一范围表现为大脑和心脏的缺血性血管疾病以及骨关节炎(关节的典型慢性非致命性疾病)造成的巨大损失。所有这些情况都会导致广泛的死亡率和发病率，造成高昂的护理费用，并损害生活质量；因此，内科及其专科的医疗保健提供者非常重要。除了它们的临床重要性，这些疾病也是与其基本病理生理学相关的研究的前沿。本次研讨会的第一部分介绍了炎症过程的基本机制的一些最新见解，包括内皮细胞-白细胞相互作用、介质释放和组织损伤；这些方面被纳入随后正在考虑的疾病状态的陈述中，以允许更合理的治疗干预措施，以限制脑、心脏和关节的损害。虽然由于篇幅有限没有详细讨论，但现在出现的治疗方式说明了将基础研究转化为药理学和临床合作的最佳范例，目的是延长患者的生命周期并提高其质量。
David Hamerman, MD,* Joan W. Berman, PhD, t Gregory W. Albers, MD,* David L. Brown, MD, § and David Silver, MDv avid Hamerman, MD: As individuals age, they are in-D creasingly affected by diseases that result in mortality and morbidity. The conditions considered in this symposium are particularly representative of those that internists observe in their encounters with an increasing number of older patients, especially the “oldest old,”’and span the range from an acute fatal event, to an acute attack with associated morbidity, to only chronicity. This range is represented by the formidable toll imposed by ischemic vascular disease of the brain and heart and by osteoarthritis, the prototypical chronic, nonfatal disease of the joints. All these conditions result in widespread mortality and morbidity, impose high costs of care, and impair quality of life; thus, they are extremely important for consideration by healthcare providers in internal medicine and its specialties. In addition to their clinical importance, these conditions are also in the forefront of research relating to their basic pathophysiology. The first section of this Symposium introduces some of the newer insights in the fundamental mechanisms of the inflammatory process, including endothelial cell-leukocyte interactions, release of mediators, and tissue injury; these aspects are incorporated into the subsequent presentations of the disease states under consideration to permit more rational therapeutic interventions to limit damage in the brain, heart, and joint. Although not discussed in detail because of space limitations, the therapeutic modalities now emerging illustrate the best example of the translation of basic research to pharmacological and clinical collaborations, with the aim of extending the patient’s duration of life and improving its quality.