Relative serum amyloid A (SAA) values: the influence of SAA1 genotypes and corticosteroid treatment in Japanese patients with rheumatoid arthritis
Relative serum amyloid A (SAA) values: the influence of SAA1 genotypes and corticosteroid treatment in Japanese patients with rheumatoid arthritis
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相对血清淀粉样蛋白 A (SAA) 值：SAA1 基因型和皮质类固醇治疗对日本类风湿关节炎患者的影响
DOI：
10.1136/ard.60.2.124
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发表时间：
2001
影响因子：
27.4
通讯作者：
J. Igari
中科院分区：
文献类型：
--
作者：
T. Yamada;Y. Okuda;K. Takasugi;K. Itoh;J. Igari
目的：（1）确定日本类风湿性关节炎（RA）患者血清淀粉样蛋白A（SAA）蛋白的血清浓度是否受SAA 1等位基因的影响，如先前在健康对照组中所示;（2）基于这种等位基因偏倚，分析哪些因素影响这些患者的相对SAA值。方法对316例日本RA患者的SAA和C反应蛋白（CRP）浓度以及SAA 1基因型进行测定。将相对SAA值评价为SAA/CRP比值。结果3组SAA 1纯合子的SAA/CRP比值以1.5/1.5组最高（平均9.0，p<0.01），其次为1.3/1.3组（平均7.2，NS vs 1.1/1.1组）和1.1/1.1组（平均4.0）。无论是否存在等位基因1.5，接受皮质类固醇治疗的患者SAA/CRP比值均显著升高。结论SAA 1.5等位基因和糖皮质激素治疗对血清SAA浓度有积极影响。这些发现在评估炎性疾病中SAA浓度以及考虑淀粉样变性的病因或治疗时很重要。
OBJECTIVES (1) To determine whether serum concentration of serum amyloid A (SAA) protein is influenced by the SAA1 allele in Japanese patients with rheumatoid arthritis (RA) as previously shown in a healthy control group; and (2) to analyse what factors, based on such an allelic bias, influence the relative SAA values of those patients. METHODS SAA and C reactive protein (CRP) concentrations together with SAA1 genotypes were determined in 316 Japanese patients with RA. The relative SAA values were evaluated as an SAA/CRP ratio. RESULTS Comparison of the three SAA1 homozygote groups showed that the SAA/CRP ratio was highest in the 1.5/1.5 group (mean 9.0, p<0.01v the other two homozygote groups) followed by the 1.3/1.3 group (mean 7.2, NS v the 1.1/1.1 group) and the 1.1/1.1 group (mean 4.0). The SAA/CRP ratio was significantly higher in patients receiving corticosteroids regardless of the presence of allele 1.5. No clear differences in the ratio between patients with or without amyloidosis were found. CONCLUSION The SAA1.5 allele and corticosteroid treatment had a positive influence on SAA concentrations in serum. These findings are important when evaluating SAA concentration in inflammatory diseases and when considering the cause or treatment of amyloidosis.
DOI：
10.1016/0925-4439(94)00076-3
发表时间：
1995-01-25
影响因子：
6.2
作者：
LIEPNIEKS, JJ;KLUVEBECKERMAN, B;BENSON, MD
通讯作者：
BENSON, MD
来自单个个体的多种形式的淀粉样蛋白相关血清蛋白 SAA 的氨基酸结构。
影响因子：
2.9
作者：
Dwulet,FE;Wallace,DK;Benson,MD
通讯作者：
Benson,MD