Tumour marker detection in oesophageal carcinoma
Tumour marker detection in oesophageal carcinoma
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DOI：
10.1016/s0748-7983(96)92998-4
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发表时间：
1996-10-01
期刊：
影响因子：
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通讯作者：
Hennessy, TPJ
中科院分区：
文献类型：
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作者：
Mealy, K;Feely, J;Hennessy, TPJ
对58例食道癌患者的肿瘤标志物CEA、CA19-9、CA125和SCC水平进行了检测，并与良性食管病患者和正常人进行了比较。食道癌患者CEA、CA19-9显著升高，而CEA、CA19-9、CA125和SCC的个体敏感度分别为28%、34%、10%和32%。所有标志物联合检测的敏感性为%，特异性为80%。在食管鳞癌和腺癌之间，联合肿瘤标志物的敏感性没有差异。标记物水平在治疗过程中没有发生一致的变化，肿瘤标记物水平与疾病分期或短期存活期没有明显的相关性。这些结果表明，肿瘤标志物对食道癌筛查的敏感性太低，对正在接受治疗的患者的预后意义不大。
Levels of the tumour markers CEA, CA 19-9, CA 125 and SCC were measured in 58 patients presenting with oesophageal carcinoma and compared with levels in patients with benign oesophageal disease and levels in normal volunteers. CEA and CA 19-9 were significantly increased in the patients with oesophageal cancer, however, individual sensitivity for CEA, CA 19-9, CA 125 and SCC was only 28, 34, 10, and 32%, respectively. The combined sensitivity of all markers was 64% and specificity was 80%. There was no difference in combined tumour marker sensitivity between squamous or adenocarcinomas of the oesophagus. No consistent change in marker levels occurred with treatment, and tumour marker levels could not be significantly correlated with stage of disease or short-term survival. These results indicate that tumour marker sensitivity is too low for oesophageal cancer screening and has poor prognostic significance in those undergoing treatment.