Principles of organization of the vertebrate olfactory glomerulus: an hypothesis.
Principles of organization of the vertebrate olfactory glomerulus: an hypothesis.
复制标题
脊椎动物嗅球的组织原理：一个假设。
DOI：
10.1016/0306-4522(86)90119-3
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发表时间：
1986
期刊：
影响因子：
3.3
通讯作者：
MontiGraziadei,GA
中科院分区：
文献类型：
--
作者：
Graziadei,PP;MontiGraziadei,GA
1875年，高尔基用他经典的浸渍法首次证明了嗅觉神经元起源于嗅神经上皮。将它们的轴突送入嗅球，在那里它们形成特征性的球状结构。在肾小球中，轴突分支并与僧帽细胞的顶端树突相互作用（图1）。卡哈尔和许多其他人证实并扩展了这些种子观察结果，随后在光镜和电镜水平上研究了嗅球的亲密性质。7 I）。我？，JO？？最近，免疫组织化学技术的应用极大地提高了我们对肾小球复杂性的认识（综述见参考文献26），但决定其初始形成的机制还不清楚。然而，在很大程度上是未知的，很少在文献中讨论。然而，这些机制必须存在;我们的实验表明，除非满足特殊要求，否则肾小球不会形成。肾小球的存在也必须具有功能上的重要性，并且揭示有助于其形成和维持的事件可能有助于理解其在嗅觉信息编码中的作用。与其他神经系统中发生的现象以及一般神经系统中决定细胞连接的现象进行类比（综述见参考文献24和33 a）。我们可以承认，生长的嗅觉轴突通过头尾向梯度和颅内存在的可扩散位置信号被引导到僧帽细胞：肾小球形成可以随后发生，用于存在于输入-靶细胞的膜水平的细胞识别过程。我们也可以承认，一个二尖瓣细胞的突触饱和可以指导随后生长的轴突。从不同的感官区域
Golgi in 1875 was the first to demonstrate, with his classical impregnation method, that the olfactory sensor-y neurons, originating in the olfactory neuroepithelium. send their axons into the olfactory bulb where they form characteristic glomerular structures. In the glomerulus, the axons branch and interact with the apical dendrites of the mitral cells (Fig. 1)‘” Cajal and many others confirmed and expanded these seminal observations and the intimate nature of the olfactory glomeruli has been subsequently investigated at both the light and electron microscope levels 1.4. 7 I). i?, JO??Recently, the availability of immunohistochemical techmques has greatly enhanced our understanding of the complexity of the glomeruli (for a review see Ref. 26) but the mechanisms that determine their initial formation are. however, largely unknown and are seldom discussed in the literature. Yet, these mechanisms must exist; our experiments have shown that formation of glomeruli does not occur unless spccitic requirements are met. The presence of the glomeruli must also have a functional significance and the uncovering of the events that contribute to their formation and maintenance through life may help in the understanding of their role in the coding of olfactory information. Bq analogy with the phenomena occurring in other scnscrry systems as well as with those determining cellular connectivity in the nervous system in general (for reviews see Refs 24 and 33a). we could admit that the growing olfactory axons are guided to the mitral cells by a craniocaudal gradient and the intracranial prest’nce of a diffusible positional signal: glomerular formation could occur subsequently for a process of cell recognition existing at the membrane level of the input-target cells. We could also admit that synaptic satur-ation of one mitral cell could direct subsequently growing axons. from different areas of the sensory