Gels and liposomes in optimized ocular drug delivery:: Studies on ciprofloxacin formulations
Gels and liposomes in optimized ocular drug delivery:: Studies on ciprofloxacin formulations
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DOI：
10.1016/j.ijpharm.2007.04.013
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发表时间：
2007-10-01
影响因子：
5.8
通讯作者：
Antal, Istvan
中科院分区：
文献类型：
--
作者：
Budai, Livia;Hajdu, Maria;Antal, Istvan
使用基于凝胶和脂质体的制剂开发了含有环丙沙星（CPFX）的治疗系统，以最大限度地减少结膜囊中的泪液驱动稀释，这是眼科学长期追求的目标。通过适当的方法研究制剂的理化性质（pH、渗透压、粘度、膨胀性、膜流动性和体外释放速率）。对于凝胶制备，以各种浓度施加生物粘附性聚（乙烯醇）和聚甲基丙烯酸衍生物。在我们的脂质体支持的载体系统中，来自卵磷脂和α-L-二棕榈酰-磷脂酰胆碱的多层囊泡提供包封剂。应用电子顺磁共振（EPR）光谱研究眼用制剂中的分子相互作用。在我们的制剂中使用的聚合物水凝胶确保了稳定和延长的活性成分释放。此外，将CPFX封装到脂质体中延长了抗菌剂的体外释放，这取决于囊泡的脂质组成。(C)2007 Elsevier B. V.保留所有权利。
Ciprofloxacin (CPFX) containing therapeutic systems were developed using gel- and liposome-based formulations to minimize tear-driven dilution in the conjunctival sac, a long-pursued objective in ophthalmology. Physicochemical properties (pH, osmolarity, viscosity, expansivity, membrane fluidity and in vitro CPFX release rate) of the preparations were studied by the appropriate methods. For gel preparation, the bioadhesive poly(vinyl alcohol) and polymethacrylic acid derivatives were applied in various concentrations. In our liposome-supported carrier systems, multilamellar vesicles from lecithin and alpha-L-dipalmithoyi-phosphatidylcholine provided the encapsulating agent. Electron paramagnetic resonance (EPR) spectroscopy was applied to study the molecular interactions in the ophthalmic formulations. The polymer hydrogels used in our preparations ensured a steady and prolonged active ingredient release. In addition, encapsulation of the CPFX into liposomes prolonged the in vitro release of the antibacterial agent depending on the lipid composition of the vesicles. (C) 2007 Elsevier B.V. All rights reserved.