Cutaneous innervation density in the allodynic form of postherpetic neuralgia
Cutaneous innervation density in the allodynic form of postherpetic neuralgia
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DOI：
10.1006/nbdi.1996.0021
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发表时间：
1996-01-01
影响因子：
6.1
通讯作者：
Fields, HL
中科院分区：
文献类型：
--
作者：
Rowbotham, MC;Yosipovitch, G;Fields, HL
在18例慢性带状疱疹后神经痛（PHN）患者中探讨了传入阻滞、感觉功能和疼痛之间的关系。在疼痛的皮肤区域定量测量温暖、冷却和热疼痛的主观阈值，并与正常对侧皮肤进行比较。在受影响区域对异常性疼痛的严重程度进行分级。从最疼痛的皮肤区域取两个3 mm打孔活检组织，从未受影响的对侧镜像皮肤取一个。免疫荧光与轴突标记PGP 9.5揭示了减少神经支配的表皮，真皮-表皮交界处，和外分泌汗腺在PHN皮肤的密度。在疼痛的PHN皮肤中，神经支配密度的减少与热感觉缺陷的大小呈正相关。然而，皮肤神经支配的丧失与异常性疼痛呈负相关，表明自发活动和/或致敏的存活皮肤初级传入伤害感受器有助于PHN疼痛和异常性疼痛。(C)出版社：Academic Press，Inc.
The relationship between deafferentation, sensory function, and pain was explored in 18 subjects with chronic postherpetic neuralgia (PHN). Subjective thresholds for warmth, cooling, and heat pain were measured quantitatively in painful skin areas and compared with normal contralateral skin. The severity of allodynia was graded in the affected area. Two 3-mm punch biopsies were taken from the most painful skin area and one from unaffected contralateral mirror-image skin. Immunofluorescence with the axonal marker PGP 9.5 revealed a reduction in density of innervation of the epidermis, the dermal-epidermal junction, and the eccrine sweat glands in PHN skin. In painful PHN skin, the reduction in innervation density was positively correlated with the magnitude of the thermal sensory deficits. However, loss of cutaneous innervation was inversely correlated with allodynia, indicating that surviving cutaneous primary afferent nociceptors that are spontaneously active and/or sensitized contribute to PHN pain and allodynia. (C) 1996 Academic Press, Inc.