Beyond pregnancy: modulation of trophoblast invasion and its consequences for fetal growth and long-term children's health
Beyond pregnancy: modulation of trophoblast invasion and its consequences for fetal growth and long-term children's health
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DOI：
10.1016/j.jri.2014.04.002
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发表时间：
2014-10-01
影响因子：
3.4
通讯作者：
Lash, Gendie E.
中科院分区：
文献类型：
--
作者：
O'Tierney-Ginn, Perrie F.;Lash, Gendie E.
上皮外滋养细胞（EVT）侵入母体组织是成功妊娠的关键步骤，EVT侵入过多或不足与妊娠并发症有关。这些妊娠并发症包括先兆子痫和胎儿生长受限，这两种情况都与出生时母体和胎儿的发病率和死亡率有关，并且在这些情况下出生的婴儿成年后患心血管疾病、糖尿病和肥胖的风险增加。此外，患有先兆子痫的女性在以后的生活中患心血管疾病的风险也更大。许多因素，蛋白质和环境，已被证明通过不同的机制在体外上调和下调这一过程。在该系统的调节中观察到的冗余表明，一个因素的失调可能不会导致EVT侵袭的病理状况，许多不同因素的相对局部浓度可能更重要。这篇综述文章探讨了调节EVT侵袭作为妊娠受先兆子痫和胎儿生长受限影响的治疗靶点的可能性，或者需要集中在整体细胞活性的调节上，而不是一个特定的因素。2014爱思唯尔爱尔兰有限公司版权所有。
Invasion of extravillous trophoblast cells (EVTs) into the maternal tissues is a key step in the development of a successful pregnancy, excessive and insufficient EVT invasion being associated with pregnancy complications. These pregnancy complications include preeclampsia and fetal growth restriction, both of which are associated with maternal and fetal morbidity and mortality at the time of birth and with increased risk of cardiovascular disease, diabetes and obesity in adult life for infants born from these conditions. In addition, women who develop preeclampsia are also at a greater risk of cardiovascular disease in later life. Many factors, protein and environmental, have been shown to both up- and down-regulate this process in vitro via different mechanisms. The redundancy observed in the regulation of this system suggests that-dysregulation of one factor may not contribute to the pathological conditions of EVT invasion and that the relative local concentrations of many different factors may be more important. This review article explores the possibility that the modulation of EVT invasion as a therapeutic target for pregnancies affected by preeclampsia and fetal growth restriction may not be possible or needs to concentrate on the modulation of cell activity as a whole and not of one particular factor. (C) 2014 Elsevier Ireland Ltd. All rights reserved.