Spinal cord axonal loss in multiple sclerosis: a post‐mortem study
Spinal cord axonal loss in multiple sclerosis: a post‐mortem study
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多发性硬化症中的脊髓轴突丢失：尸检研究
DOI：
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发表时间：
1999
影响因子：
5
通讯作者：
Esiri
中科院分区：
文献类型：
--
作者：
Ganter;Prince;Esiri
轴突损伤对多发性硬化症(MS)的临床残疾的贡献越来越引起人们的兴趣。本文报告了23名男性和20名女性MS患者C3和T2的脊髓外侧白质柱所占面积和皮质脊髓束的神经纤维密度的尸检，这些患者在这些水平上缺乏斑块，并在31名对照组中进行了尸检，尽管大多数人有一些神经系统疾病，但没有颈或脊髓胸疾病的迹象。通过对侧柱轮廓的低倍图像分析，男性MS的侧柱横截面积在C3和T2分别减少了17%和21%，女性在C3和T2分别减少了13%和18%。这些下降在男性的两个水平上都是显著的(在C3的P<；0.004和在T2 的P<；0.009)，但女性只在T2(P<；0.03)。交叉锥体束所占区域200个显微视野的自动图像分析结果显示，男性C3和T2神经纤维密度分别下降41%和42%，女性C3和T2均下降19%。这些下降在男性(在C3和T2 分别为P<；0.003和P<；0.000)和T2仅在女性(P<；0.045)两个水平上都同样显著。在MS中，男性C3(P<；0.004)和T2(P<；0.000)的神经纤维密度显著低于女性。在对照组中，男性和女性之间的这些参数没有差异。总神经纤维密度的减少完全是由于细小神经纤维的减少(横截面积小于5 μm2 )。大纤维密度(横截面面积为5 μm2或更大)未见明显减少。结论：MS患者在C3、T2节段可见大量轴突丢失和脊髓侧柱白质萎缩，部分患者可在病程早期发现这些改变。
There is increasing interest in the contribution that axonal damage may make to clinical disability in multiple sclerosis (MS). The present study reports a post‐mortem examination of the area occupied by the lateral white matter columns of the spinal cord and nerve fibre density in the corticospinal tracts at C3 and T2 in 23 males and 20 females with MS, who lacked plaques at these levels, and in 31 controls who, although most had had some neurological disease, showed no sign of cervical or spinal cord thoracic disease. The lateral column cross‐sectional area, measured by low power image analysis of the outlined lateral columns, was reduced in MS by 17% at C3 and 21% at T2 in males and by 13% at C3 and 18% at T2 in females. These reductions were significant at both levels in males (P<0.004 at C3 and P<0.009 at T2 ) but only at T2 in females (P<0.03). The nerve fibre density, measured by automatic image analysis of ×200 microscopic fields in the region occupied by the crossed pyramidal tracts, was reduced by 41% at C3 and 42% at T2 in males and by 19% at both C3 and T2 in females. These reductions were likewise significant at both levels in males (P<0.003 and P<0.000 at C3 and T2 , respectively) and T2 only in females (P<0.045). In MS, nerve fibre density was significantly lower at C3 (P<0.004) and T2 (P<0.000) in males than females. No differences were seen in these parameters between males and females in controls. The reductions in total nerve fibre densities were entirely accounted for by reductions in small nerve fibres (cross sectional area less than 5 μm2 ). No significant reductions were seen in large fibre (cross sectional area 5 μm2 or more) densities. It is concluded that substantial axonal loss and spinal cord lateral column white matter atrophy occur at C3 and T2 in MS, and that these changes can be detected in some patients from early in the course of the disease.
影响因子：
158.5
作者：
Trapp, BD;Peterson, J;Bö, L
通讯作者：
Bö, L