Ferroptosis and Brain Injury
Ferroptosis and Brain Injury
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DOI：
10.1159/000496922
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发表时间：
2019-01-01
影响因子：
2.9
通讯作者：
Dixon, Scott J.
中科院分区：
文献类型：
--
作者：
Magtanong, Leslie;Dixon, Scott J.
铁死亡是一种非凋亡形式的细胞死亡，其特征是有毒脂质活性氧的铁依赖性积累。小分子筛选和随后的优化已经产生了有效的特异性激活剂和抑制剂。这些化合物已被用于解剖致死机制，并涉及在许多组织中观察到的病理性细胞死亡事件的过程，包括大脑。事实上，铁下垂是中风、脑出血和其他急性脑损伤中细胞死亡的重要机制，也可能在某些退行性脑疾病中发挥作用。突出的问题包括鉴定铁下垂分子标记的实际需要，这些分子标记可用于在体内检测和研究这一过程，以及更基本的问题，即理解铁下垂与损伤期间可能在大脑中触发的其他形式的细胞死亡之间的关系。
Ferroptosis is a nonapoptotic form of cell death characterized by the iron-dependent accumulation of toxic lipid reactive oxygen species. Small-molecule screening and subsequent optimization have yielded potent and specific activators and inhibitors of this process. These compounds have been employed to dissect the lethal mechanism and implicate this process in pathological cell death events observed in many tissues, including the brain. Indeed, ferroptosis is emerging as an important mechanism of cell death during stroke, intracerebral hemorrhage, and other acute brain injuries, and may also play a role in certain degenerative brain disorders. Outstanding issues include the practical need to identify molecular markers of ferroptosis that can be used to detect and study this process in vivo, and the more basic problem of understanding the relationship between ferroptosis and other forms of cell death that can be triggered in the brain during injury.