Regulation of gene expression by microRNA in HCV infection and HCV-mediated hepatocellular carcinoma.
Regulation of gene expression by microRNA in HCV infection and HCV-mediated hepatocellular carcinoma.
复制标题
DOI：
10.1186/1743-422x-11-64
复制
发表时间：
2014-04-01
期刊：
影响因子：
4.8
通讯作者：
Saksena NK
中科院分区：
文献类型：
--
作者：
Gupta P;Cairns MJ;Saksena NK
MicroRNA（miRNA）对丙型肝炎病毒（HCV）的复制和HCV相关性肝细胞癌（HCC）的表现有着深远的影响。特别是miR-122在肝脏中高度富集，并已显示与HCV相互作用，表明该病毒已进化为破坏和操纵宿主基因沉默机制以支持其生命周期。因此，miR-122和其他miRNA可能在HCV感染的病理生理学中发挥重要作用。miRNAs对转录后基因调控的改变可能在慢性肝病和肝细胞癌的表现中起关键作用。对HCV-宿主miRNA相互作用的理解将最终导致针对HCV感染和HCV介导的HCC的治疗方式的设计，并且还可能提供指导治疗选择的重要生物标志物。本文就miRNA及其基因表达在HCV感染和肝细胞癌中的作用以及miRNA作为未来治疗靶点的可能作用作一综述。
MicroRNA (miRNA) exert a profound effect on Hepatitis C virus (HCV) replication and on the manifestation of HCV-associated hepatocellular carcinoma (HCC). miR-122 in particular, is highly enriched in liver and has been shown to interact with HCV, suggesting this virus has evolved to subvert and manipulate the host gene silencing machinery in order to support its life cycle. It is therefore likely that miR-122 and other miRNAs play an important role in the pathophysiology of HCV infection. The changes in post-transcriptional gene regulation by the miRNAs may play a key role in the manifestation of chronic liver disease and hepatocellular carcinoma. Understanding of HCV-host miRNA interactions will ultimately lead to the design of therapeutic modalities against HCV infection and HCV-mediated HCC and may also provide important biomarkers that direct treatment options. Here, we review the current knowledge on the role of miRNA and gene expression on HCV infection and hepatocellular carcinoma, in addition to the possible role of miRNA as future therapeutic targets.