Value-guided remapping of sensory cortex by lateral orbitofrontal cortex
Value-guided remapping of sensory cortex by lateral orbitofrontal cortex
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DOI：
10.1038/s41586-020-2704-z
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发表时间：
2020-09-03
期刊：
影响因子：
64.8
通讯作者：
Helmchen, Fritjof
中科院分区：
文献类型：
--
作者：
Banerjee, Abhishek;Parente, Giuseppe;Helmchen, Fritjof
外侧眶额皮层神经元与感觉皮层的动态相互作用实现了依赖于历史和基于错误的价值预测计算，为灵活决策提供了必要的可塑性。适应性行为关键取决于灵活决策，在哺乳动物中，灵活决策依赖于额叶皮层，特别是眶额皮层（OFC）（1-9）。OFC如何编码决策变量并指导感觉区域指导适应行为是关键的开放问题。在这里，我们开发了一个反向学习任务的头部固定的小鼠，使用双光子钙成像监测外侧OFC的神经元的活动，并调查如何OFC动态地与初级体感皮层（S1）的相互作用。小鼠学会了区分“去”和“不去”的触觉刺激（10，11），并在刺激-奖励偶然性逆转（“规则转换”）时调整其行为。成像个别神经元纵向跨越所有的行为阶段揭示了一个独特的参与S1和横向OFC，与S1神经活动反映初始任务学习，而横向OFC神经元响应显着和短暂的规则开关。我们确定了从横向OFC到S1的直接长期预测，可以将此活动反馈到S1作为值预测误差。这种自上而下的信号通过功能性地重新映射对奖励历史敏感的神经元亚群的反应来更新S1中的感觉表征。功能重映射关键依赖于自上而下的反馈，因为外侧OFC神经元的化学基因沉默破坏了逆转学习，以及S1的可塑性。因此，外侧OFC与感觉皮层的动态相互作用实现了对价值预测至关重要的计算，这些计算依赖于历史和错误，为灵活的决策提供了必要的可塑性。
Dynamic interaction of neurons in lateral orbitofrontal cortex with the sensory cortex implements value-prediction computations that are history dependent and error based, providing plasticity essential for flexible decision-making.Adaptive behaviour crucially depends on flexible decision-making, which in mammals relies on the frontal cortex, specifically the orbitofrontal cortex (OFC)(1-9). How OFC encodes decision variables and instructs sensory areas to guide adaptive behaviour are key open questions. Here we developed a reversal learning task for head-fixed mice, monitored the activity of neurons of the lateral OFC using two-photon calcium imaging and investigated how OFC dynamically interacts with primary somatosensory cortex (S1). Mice learned to discriminate 'go' from 'no-go' tactile stimuli(10,11)and adapt their behaviour upon reversal of stimulus-reward contingency ('rule switch'). Imaging individual neurons longitudinally across all behavioural phases revealed a distinct engagement of S1 and lateral OFC, with S1 neural activity reflecting initial task learning, whereas lateral OFC neurons responded saliently and transiently to the rule switch. We identified direct long-range projections from lateral OFC to S1 that can feed this activity back to S1 as value prediction error. This top-down signal updated sensory representations in S1 by functionally remapping responses in a subpopulation of neurons that was sensitive to reward history. Functional remapping crucially depended on top-down feedback as chemogenetic silencing of lateral OFC neurons disrupted reversal learning, as well as plasticity in S1. The dynamic interaction of lateral OFC with sensory cortex thus implements computations critical for value prediction that are history dependent and error based, providing plasticity essential for flexible decision-making.