CD8+ LYMPHOCYTE-ACTIVATION AT HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 SEROCONVERSION - DEVELOPMENT OF HLA-DR+ CD38- CD8+ CELLS IS ASSOCIATED WITH SUBSEQUENT STABLE CD4+ CELL LEVELS
CD8+ LYMPHOCYTE-ACTIVATION AT HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 SEROCONVERSION - DEVELOPMENT OF HLA-DR+ CD38- CD8+ CELLS IS ASSOCIATED WITH SUBSEQUENT STABLE CD4+ CELL LEVELS
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DOI：
10.1093/infdis/170.4.775
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发表时间：
1994-10-01
影响因子：
6.4
通讯作者：
SEMINARA, D
中科院分区：
文献类型：
--
作者：
GIORGI, JV;HO, HN;SEMINARA, D
通过三色流式细胞术对随后成为人类免疫缺陷病毒1型（HIV）血清阳性的同性恋男性的活化CD 8（+）淋巴细胞亚群（由活化抗原HLA-DR和CD 38的膜表达定义）进行计数。在血清转换时以及6个月和12个月后，在所有受试者中均观察到显著的CD 8（+）细胞活化。HLA-DR（+）CD 38（+）CD 8（+）细胞群具有强效的直接HIV细胞毒性T细胞活性，在所有受试者血清转换时均显著升高。在一些男性中，这些水平在感染的第一年仍然升高。在接下来的5年里，这些人的CD 4（+）细胞水平稳定，而其他人则没有。长期存活者（血清学阳性9年，> 800个CD 4+细胞/mm 3）的这一亚群水平也升高，尽管其他活化的CD 8+细胞很少。因此，HLA-DR（+）CD 38（-）CD 8（+）细胞的选择性升高是随后稳定的HIV疾病的标志。
Subsets of activated CD8(+) lymphocytes defined by membrane expression of the activation antigens HLA-DR and CD38 were counted by three-color flow cytometry in homosexual men who subsequently became seropositive for human immunodeficiency virus type 1 (HIV). Profound CD8(+) cell activation was seen in all subjects at seroconversion and 6 and 12 months later. The HLA-DR(+) CD38(+) CD8(+) cell population, which has potent direct HIV cytotoxic T cell activity, was markedly elevated at seroconversion in all subjects. In some men, these levels remained elevated throughout the first year of infection. During the next 5 years, these men had stable CD4(+) cell levels, whereas the others did not. Long-term survivors (seropositive for 9 years, > 800 CD4(+) cells/mm(3)) also had elevated levels of this subset, despite few other activated CD8(+) cells. Thus, selective elevation of HLA-DR(+) CD38(-) CD8(+) cells was a marker of subsequent stable HIV disease.