Clinical in vivo confocal microscopy of the human cornea in health and disease
Clinical in vivo confocal microscopy of the human cornea in health and disease
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DOI：
10.1016/j.preteyeres.2009.11.001
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发表时间：
2010-01-01
影响因子：
17.8
通讯作者：
McGhee, C. N. J.
中科院分区：
文献类型：
--
作者：
Niederer, R. L.;McGhee, C. N. J.
共聚焦显微镜能够对活体角膜进行显微结构分析，使人们能够对健康、遗传性和获得性角膜疾病的角膜微结构有新的了解。这种角膜检查方法正在以指数的方式发展，研究和临床应用的快速增长反映了技术的快速进步。虽然最初体内共聚焦显微镜的证据基础主要是小病例研究，但近年来有收集定量数据的趋势，以努力更好地描述健康和疾病之间的关系。共聚焦显微镜已经在临床上被用于辅助诊断感染性角膜炎，特别是棘阿米巴和真菌性角膜炎，并在角膜营养不良的诊断和表型分析中发挥了作用。本文综述了健康和疾病中人体角膜的活体共聚焦显微镜，并对这项新技术的临床和研究应用进行了审查。(C)2009爱思唯尔有限公司。保留所有权利。
Confocal microscopy enables microstructural analysis of the in vivo cornea, allowing fresh insight into corneal microstructure in health, and in inherited and acquired corneal disease. This method of corneal examination is evolving in an exponential fashion, with rapid advances in technology being mirrored by rapid growth in both research and clinical applications. Whilst initially the evidence base for in vivo confocal microscopy consisted largely of small case studies, in recent years there has been a trend towards collecting quantitative data in an effort to better delineate between heath and disease. Confocal microscopy has been utilised clinically to aid in the diagnosis of infectious keratitis, in particular Acanthamoeba and fungal keratitis, and has also established a role in the diagnosis and phenotyping of corneal dystrophies. This article reviews in vivo confocal microscopy of the human cornea in health and disease and examines clinical and research applications of this new technology. (C) 2009 Elsevier Ltd. All rights reserved.