Staphylococcus Δ-toxin Promotes Mouse Allergic Skin Disease by Inducing Mast Cell Degranulation Hhs Public Access
Staphylococcus Δ-toxin Promotes Mouse Allergic Skin Disease by Inducing Mast Cell Degranulation Hhs Public Access
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Y. Nakamura;J. Oscherwitz;K. Cease;Susana M. Chan;Raúl Muñoz-Planillo;M. Hasegawa;A. Villaruz;Gordon Y. C. Cheung;M. McGavin;J. Travers;M. Otto;N. Inohara;G. Núñez;M. J. M. A. E. Generated-M.-J.-M.-A.-E.-Generated-2252430255;M. O. Engineered
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作者：
Y. Nakamura;J. Oscherwitz;K. Cease;Susana M. Chan;Raúl Muñoz-Planillo;M. Hasegawa;A. Villaruz;Gordon Y. C. Cheung;M. McGavin;J. Travers;M. Otto;N. Inohara;G. Núñez;M. J. M. A. E. Generated-M.-J.-M.-A.-E.-Generated-2252430255;M. O. Engineered
特应性皮炎（AD）是一种慢性炎症性皮肤病，在工业化国家中影响15%至30%的儿童和约5%的成人1。虽然AD的发病机制尚未完全了解，但在皮肤屏障功能障碍的情况下，该疾病由异常免疫球蛋白E（IgE）免疫应答介导2。肥大细胞（MC）有助于IgE介导的过敏性疾病，包括AD 3。在激活时，MC释放其膜结合的胞质颗粒，导致在AD的发病机制和宿主防御中重要的多种分子的释放4。超过90%的AD患者在病变皮肤中定植有金黄色葡萄球菌，而大多数健康个体不携带病原体5。几种葡萄球菌外毒素（SE）可以在AD 6模型中充当超抗原和/或抗原。然而，这些SE在疾病发病机制中的作用仍不清楚。在这里，我们报告，培养上清液的S。金黄色葡萄球菌含有有效的MC脱粒活性。生化分析表明δ毒素是S.金黄色。δ-毒素诱导的MC脱粒用户可以查看、打印、复制、下载和文本和数据挖掘这些文件中的内容，用于学术研究，但始终遵守完整的用途：
Atopic dermatitis (AD) is a chronic inflammatory skin disease that affects 15 to 30% of children and ~5% of adults in industrialized countries 1. Although the pathogenesis of AD is not fully understood, the disease is mediated by an abnormal immunoglobulin E (IgE) immune response in the setting of skin barrier dysfunction 2. Mast cells (MCs) contribute to IgE-mediated allergic disorders including AD 3. Upon activation, MCs release their membrane-bound cytosolic granules leading to the release of multiple molecules that are important in the pathogenesis of AD and host defense 4. More than 90% of AD patients are colonized with Staphylococcus aureus in the lesional skin whereas most healthy individuals do not harbor the pathogen 5. Several Staphylococcal exotoxins (SEs) can act as superantigens and/or antigens in models of AD 6. However, the role of these SEs in disease pathogenesis remains unclear. Here, we report that culture supernatants of S. aureus contain potent MC degranulation activity. Biochemical analysis identified δ-toxin as the MC degranulation-inducing factor produced by S. aureus. MC degranulation induced by δ-toxin Users may view, print, copy, download and text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: