Age dependence of cerebral perfusion assessed by magnetic resonance continuous arterial spin labeling
Age dependence of cerebral perfusion assessed by magnetic resonance continuous arterial spin labeling
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DOI：
10.1002/jmri.20839
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发表时间：
2007-04-01
影响因子：
4.4
通讯作者：
Tosetti, Michela
中科院分区：
文献类型：
--
作者：
Biagi, Laura;Abbruzzese, Arturo;Tosetti, Michela
目的：研究脑灌注变化对年龄的正常依赖性，测量生命早期的灌注值，建立参考数据集。材料与方法：采用动脉自旋标记（ASL）技术采集44例4 ~ 78岁健康受试者的血流灌注图。回顾性地将人群分为三个年龄组：儿童、青少年和成人。计算各组灰质（GM）和白质（WM）脑血流量（CBF）平均值。研究人员对三个不同年龄组的结果进行了比较。结果：CBF值随年龄而降低（儿童GM为97 +/- 5ml / 100g /min， WM为26 +/- 1ml / 100g /min，青少年GM为79 +/- 3ml / 100g /min， WM为22 +/- 1ml / 100g /min，成人GM为58 +/- 4ml / 100g /min， WM为20 +/- 1ml / 100g /min）。定量结果表明，在儿童和成人受试者之间，脑灌注是快速下降，而不是逐渐减少，尤其是在GM。CBF的这一步骤发生在青春期，大约在16岁。结论：ASL是一种实用的定量技术，适用于儿童和成人的灌注测量。ASL灌注测量对脑成熟过程中发生的神经生理变化很敏感。
Purpose: To study the normal dependence of cerebral perfusion changes on age, to measure values of perfusion early in life, and to create a reference dataset.Materials and Methods: Perfusion maps were collected from a total of 44 healthy subjects (from four to 78 years old) using the arterial spin labeling (ASL) technique. The population was retrospectively divided into three age groups: children, teenagers, and adults. For each group, mean values of cerebral blood flow (CBF) were calculated in gray matter (GM) and white matter (WM). Results were compared across the three different age groups.Results: CBF values decreased with age (97 +/- 5 mL/100 g/minute in GM and 26 +/- 1 mL/100 g/minute in WM for the children, GM 79 +/- 3 mL/100 g/minute and WM 22 +/- 1 mL/100 g/minute for the teenagers, and GM 58 +/- 4 mL/100 g/minute, WM 20 +/- 1 mL/100 g/minute for the adults). The quantitative results suggest a rapid drop, rather than a gradual decrease, in cerebral perfusion between children and adult subjects, especially in the GM. This step in CBF occurs during adolescence, at approximately the 16th year of age.Conclusion: ASL is a practical and quantitative technique suitable for perfusion measurement in children as well as adults. Perfusion measurements with ASL appear sensitive to neurophysiological changes occurring during brain maturation.