Hippocampal network dysfunction as a mechanism of early-onset dementia after preeclampsia and eclampsia.
Hippocampal network dysfunction as a mechanism of early-onset dementia after preeclampsia and eclampsia.
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DOI：
10.1016/j.pneurobio.2020.101938
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发表时间：
2021-04
影响因子：
6.7
通讯作者：
Cipolla MJ
中科院分区：
文献类型：
--
作者：
Johnson AC;Li Z;Orfila JE;Herson PS;Cipolla MJ
先兆子痫是一种妊娠期高血压疾病，可能涉及危险的神经系统症状，如自发性癫痫发作（子痫）。尽管是妊娠状态特有的疾病，但先兆子痫和子痫在以后的生活中具有长期的神经学后果，包括相对年轻时大脑结构的变化和认知能力的下降。然而，先兆子痫对记忆和认知的中枢脑区（如海马体）的影响尚不清楚。在这里，我们提出了一个病例报告进行性和永久性的认知能力下降的妇女，有惊厥发作的证据，脑损伤的MRI。然后，我们使用正常妊娠和先兆子痫的大鼠模型来研究子痫样癫痫发作可能破坏海马功能的机制。我们发现，实验性先兆子痫导致大鼠记忆力延迟下降和海马神经可塑性的破坏。此外，妊娠期癫痫发作和先兆子痫引起急性记忆功能障碍和神经可塑性受损，但不会引起急性神经元细胞死亡。重要的是，产后5周海马功能障碍持续存在，表明癫痫引起的损伤是持久的，可能是永久性的。我们的数据提供了先兆子痫模型的第一个证据，该模型可能模拟以前先兆子痫妇女的认知能力下降，先兆子痫和子痫影响海马网络可塑性并损害记忆。
Preeclampsia is a hypertensive disorder of pregnancy that can involve dangerous neurological symptoms such as spontaneous seizures (eclampsia). Despite being diseases specific to the pregnant state, preeclampsia and eclampsia have long-lasting neurological consequences later in life, including changes in brain structure and cognitive decline at relatively young ages. However, the effects of preeclampsia on brain regions central to memory and cognition, such as the hippocampus, are unclear. Here, we present a case reporting the progressive and permanent cognitive decline in a woman that had eclamptic seizures in the absence of evidence of brain injury on MRI. We then use rat models of normal pregnancy and preeclampsia to investigate mechanisms by which eclampsia-like seizures may disrupt hippocampal function. We show that experimental preeclampsia causes delayed memory decline in rats and disruption of hippocampal neuroplasticity. Further, seizures in pregnancy and preeclampsia caused acute memory dysfunction and impaired neuroplasticity but did not cause acute neuronal cell death. Importantly, hippocampal dysfunction persisted 5 weeks postpartum, suggesting seizure-induced injury is long lasting and may be permanent. Our data provide the first evidence of a model of preeclampsia that may mimic the cognitive decline of formerly preeclamptic women, and that preeclampsia and eclampsia affect hippocampal network plasticity and impair memory.
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DOI：
10.1523/jneurosci.4022-09.2010
发表时间：
2010-02-17
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Foster KA;McLaughlin N;Edbauer D;Phillips M;Bolton A;Constantine-Paton M;Sheng M
通讯作者：
Sheng M
影响因子：
9.8
作者：
Aukes, Annet M.;Wessel, Ineke;Zeeman, Gerda G.
通讯作者：
Zeeman, Gerda G.
影响因子：
5.5
作者：
Debanne, D;Guerineau, NC;Thompson, SM
通讯作者：
Thompson, SM
影响因子：
5.5
作者：
BENARI, Y;GHO, M
通讯作者：
GHO, M
影响因子：
3.3
作者：
Harada CN;Natelson Love MC;Triebel KL
通讯作者：
Triebel KL