In Utero Exposure to Maternal Overweight or Obesity is Associated with Altered Offspring Brain Function in Middle Childhood.
In Utero Exposure to Maternal Overweight or Obesity is Associated with Altered Offspring Brain Function in Middle Childhood.
复制标题
在子宫内，母亲超重或肥胖与后代中期大脑功能的改变有关。
DOI：
10.1002/oby.22908
复制
发表时间：
2020
期刊：
影响因子：
--
通讯作者：
Tregellas,JasonR
中科院分区：
文献类型：
--
作者：
Shapiro,AllisonLB;Moore,BriannaF;Sutton,Brianne;Wilkening,Greta;Stence,Nicholas;Dabelea,Dana;Tregellas,JasonR
ObjectiveThe impact ofin uteroexposure to maternal overweight and obesity on offspring metabolic health is well documented. Neurodevelopmental outcomes among these children are, however, less well studied. To address this gap, the current study investigated brain function among 4‐ to 6‐year‐old children exposed to maternal overweight or obesity during gestation compared with that of children born to mothers with healthy BMI in pregnancy.MethodsResting‐state functional magnetic resonance imaging was used to study neuronal activity and connectivity during a passive viewing task (movie) among 101 typically developing children enrolled in the Healthy Start study, a longitudinal prebirth cohort in Colorado.ResultsForty‐nine children (48%) were exposed to maternal overweight or obesityin utero(mean age = 5 years, SD = 0.9). Children born to mothers with overweight or obesity demonstrated hyperactivity in the left posterior cingulate cortex and hypoactivity in the dorsal anterior cingulate and the supplementary motor area (P< 0.05 for all). Children born to mothers with overweight or obesity also showed ubiquitously weaker brain connectivity (P< 0.05 for all).ConclusionsThese novel results suggest altered brain function among children exposed to maternal overweight and obesityin utero.
