DNA damage and repair
DNA damage and repair
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DOI：
10.1038/nature01408
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发表时间：
2003-01-23
期刊：
影响因子：
64.8
通讯作者：
Friedberg, EC
中科院分区：
文献类型：
--
作者：
Friedberg, EC
DNA双螺旋的美学吸引力最初阻碍了DNA突变和修复的概念，这必然会干扰其原始状态。但后来人们认识到，DNA会受到持续的损伤，细胞有一系列的方法来应对这种损伤。虽然突变或修复缺陷可能会产生灾难性的后果，导致一系列人类疾病，但突变仍然是生命和进化的基础。
The aesthetic appeal of the DNA double helix initially hindered notions of DNA mutation and repair, which would necessarily interfere with its pristine state. But it has since been recognized that DNA is subject to continuous damage and the cell has an arsenal of ways of responding to such injury. Although mutations or deficiencies in repair can have catastrophic consequences, causing a range of human diseases, mutations are nonetheless fundamental to life and evolution.