Complex systems dynamics in aging: new evidence, continuing questions.
Complex systems dynamics in aging: new evidence, continuing questions.
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DOI：
10.1007/s10522-015-9584-x
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发表时间：
2016-02
期刊：
影响因子：
4.5
通讯作者：
Cohen AA
中科院分区：
文献类型：
--
作者：
Cohen AA
长期以来，人们一直认为衰老与维持体内平衡的生理系统的复杂动力学密切相关，特别是与分子调节网络的失调有关。这篇综述综合了最近的工作，这些工作开始为这种复杂的系统动力学在衰老中的重要性提供证据。现在有明确的证据表明，生理失调——复杂的调节网络维持体内平衡的能力逐渐崩溃——是这些调节网络的一个紧急特性，它在衰老中起着重要作用。它可以简单地用少量的生物标记物来测量。此外，有迹象表明，衰老过程中出现的生理过程和功能过程的重要性，这些过程不能通过明确的代谢途径轻易理解，但仍然可以精确地量化和研究。这种复杂的系统动力学在衰老中的总体作用仍然是一个重要的开放问题，为了理解它，未来的研究将需要区分和整合衰老研究的相关方面，包括衰老的多因素理论、系统生物学、生物信息学、网络方法、鲁棒性和复杂性的丧失。
There have long been suggestions that aging is tightly linked to the complex dynamics of the physiological systems that maintain homeostasis, and in particular to dysregulation of regulatory networks of molecules. This review synthesizes recent work that is starting to provide evidence for the importance of such complex systems dynamics in aging. There is now clear evidence that physiological dysregulation—the gradual breakdown in the capacity of complex regulatory networks to maintain homeostasis—is an emergent property of these regulatory networks, and that it plays an important role in aging. It can be measured simply using small numbers of biomarkers. Additionally, there are indications of the importance during aging of emergent physiological processes, functional processes that cannot be easily understood through clear metabolic pathways, but can nonetheless be precisely quantified and studied. The overall role of such complex systems dynamics in aging remains an important open question, and to understand it future studies will need to distinguish and integrate related aspects of aging research, including multi-factorial theories of aging, systems biology, bioinformatics, network approaches, robustness, and loss of complexity.
影响因子：
3.7
作者：
Pearson CA;Zeng C;Simha R
通讯作者：
Simha R