Different plant hormones regulate similar processes through largely nonoverlapping transcriptional responses
Different plant hormones regulate similar processes through largely nonoverlapping transcriptional responses
复制标题
DOI：
10.1016/j.cell.2006.05.050
复制
发表时间：
2006-08-11
期刊：
影响因子：
64.5
通讯作者：
Chory, Joanne
中科院分区：
文献类型：
--
作者：
Nemhauser, Jennifer L.;Hong, Fangxin;Chory, Joanne
小分子激素支配着植物生物学的方方面面。许多过程，如生长，是由多种激素以相似的方式调节的，最近的研究揭示了不同激素信号通路之间广泛的串扰。这些结果导致了一种建议，即一组共同的信号成分可能整合了多种激素的输入来调节生长。在这项研究中，我们通过询问不同的激素是否在拟南芥幼苗中聚集在一组共同的转录靶标上来测试这一提议。利用公开的微阵列数据，我们分析了7种激素的转录效应，包括脱落酸、赤霉素、生长素、乙烯、细胞分裂素、油菜素类固醇和茉莉酸盐。一项高灵敏度分析显示，常见靶基因的数量少得惊人。相反，不同的激素似乎调节着蛋白质家族的不同成员。我们得出结论，在拟南芥幼苗中不存在核心的转录生长调控模块。
Small-molecule hormones govern every aspect of the biology of plants. Many processes, such as growth, are regulated in similar ways by multiple hormones, and recent studies have revealed extensive crosstalk among different hormonal signaling pathways. These results have led to the proposal that a common set of signaling components may integrate inputs from multiple hormones to regulate growth. In this study, we tested this proposal by asking whether different hormones converge on a common set of transcriptional targets in Arabidopsis seedlings. Using publicly available microarray data, we analyzed the transcriptional effects of seven hormones, including abscisic acid, gibberellin, auxin, ethylene, cytokinin, brassinosteroid, and jasmonate. A high-sensitivity analysis revealed a surprisingly low number of common target genes. Instead, different hormones appear to regulate distinct members of protein families. We conclude that there is not a core transcriptional growth-regulatory module in young Arabidopsis seedlings.