Decreased plasma adiponectin is associated with insulin resistance and HDL cholesterol in overweight subjects
Decreased plasma adiponectin is associated with insulin resistance and HDL cholesterol in overweight subjects
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DOI：
10.1507/endocrj.k06-021
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发表时间：
2007-04-01
影响因子：
2
通讯作者：
Arslan, Metin
中科院分区：
文献类型：
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作者：
Altinova, Alev E.;Toruner, Fusun;Arslan, Metin
本研究旨在探讨超重和正常体重人群血浆脂联素水平及其与代谢指标的关系。该研究在46名超重受试者（20名男性，26名女性;平均年龄39.4 ± 10.2岁）和48名（19名男性，29名女性;平均年龄36.1 ± 10.6岁）性别和年龄匹配的正常体重受试者中进行。记录人体测量数据，并测量脂联素、血糖、胰岛素、血脂、总同型半胱氨酸（tHcy）和纤维蛋白原水平。采用胰岛素抵抗稳态模型（HOMA-IR）评估胰岛素抵抗指数。超重组血浆脂联素浓度（15.0 ± 4.2 ng/ml）显著低于正常体重组（17.3 ± 5.6 ng/ml）（P < 0.05）。在超重者中，脂联素水平与体重呈负相关（r =-0.35，P < 0.001），体重指数（BMI）（r =-0.28，P < 0.006），收缩压（r =-0.21，P < 0.04），空腹胰岛素HOMA-IR（r =-0.20，P <0.01）与高密度脂蛋白胆固醇（HDL-C）呈正相关（r = 0.27，P < 0.009）。低HDL-C超重组血浆脂联素水平显著低于高HDL-C超重组（P < 0.05）。多元逐步回归分析显示，BMI、HOMA-IR和HDL-C分别解释脂联素水平12%、20%和15%的变异。这些发现可能表明，循环脂联素与胰岛素抵抗和HDL-C水平相关，而与超重受试者的BMI无关。
The purpose of this study was to investigate plasma adiponectin concentration and its relation with metabolic parameters in overweight and normal weight subjects. The study was carried out in 46 overweight subjects (20 male, 26 female; mean age 39.4 +/- 10.2 years) and 48 (19 male, 29 female; mean age 36.1 +/- 10.6 years) sex- and age-matched normal weight subjects. Anthropometric measurements were recorded and adiponectin, glucose, insulin, lipid profile, total homocysteine (tHcy) and fibrinogen levels were measured. The insulin resistance index was assessed by homeostasis model assessment for insulin resistance (HOMA-IR). Plasma mean adiponectin concentrations of the overweight subjects were significantly lower than those of normal weight subjects (15.0 +/- 4.2 vs 17.3 +/- 5.6 ng/ml) (P < 0.05). In overweight subjects, adiponectin levels negatively correlated with body weight (r = -0.35, P < 0.001), body mass index (BMI) (r = -0.28, P < 0.006), systolic blood pressure (r = -0.21, P < 0.04), fasting insulin (r=-0.19, P < 0.01) and HOMA-IR (r=-0.20, P < 0.01) and positively with high-density lipoprotein cholesterol (HDL-C) (r = 0.27, P < 0.009). Overweight subjects with low HDL-C levels had significantly decreased plasma adiponectin levels compared to those with high HDL-C levels (P < 0.05). Multiple regression analysis revealed that BMI, HOMA-IR and HDL-C explained 12%, 20% and 15% variance of the adiponectin concentrations. These findings may suggest that circulating adiponectin is associated with insulin resistance and HDL-C levels independent from BMI in overweight subjects.