Repurposing strategies for tropical disease drug discovery.
Repurposing strategies for tropical disease drug discovery.
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DOI：
10.1016/j.bmcl.2016.03.103
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发表时间：
2016-06-01
影响因子：
2.7
通讯作者：
Pollastri MP
中科院分区：
文献类型：
--
作者：
Klug DM;Gelb MH;Pollastri MP
被忽视的热带病和发展中世界的其他疾病，如疟疾，吸引的研究投资与它们对世界各地人类健康的影响相比低得不成比例。因此，启动新药发现计划的实用方法应运而生，这些计划将现有的化学物质重新用作新药或优化的新起点。在这份摘要中，我们描述了不同的非专利药物再利用方法的应用，并提供了一种将这些方法彼此区别开来的方法。其中包括药物再利用、靶向再利用、靶类再利用和铅再利用。
Neglected tropical diseases (NTDs) and other diseases of the developing world, such as malaria, attract research investments that are disproportionately low compared to their impact on human health worldwide. Therefore, pragmatic methods for launching new drug discovery programs have emerged that repurpose existing chemical matter as new drugs or new starting points for optimization. In this Digest we describe applications of different repurposing approaches for NTDs, and provide a means by which these approaches may be differentiated from each other. These include drug repurposing, target repurposing, target class repurposing, and lead repurposing.