Dendritic Cell Vaccination in Non-Small Cell Lung Cancer: Remodeling the Tumor Immune Microenvironment.
Dendritic Cell Vaccination in Non-Small Cell Lung Cancer: Remodeling the Tumor Immune Microenvironment.
复制标题
作者：
非小细胞肺癌（NSCLC）仍然是全球主要的死亡原因之一。虽然NSCLC具有可以潜在地引发T细胞应答的抗原，但是缺陷的肿瘤抗原呈递和T细胞活化阻碍宿主抗肿瘤免疫应答。NSCLC肿瘤微环境（TME）由可促进或对抗肿瘤生长的细胞和可溶性介质组成。TME的组成在促进肿瘤发生和决定对免疫疗法的抗肿瘤免疫应答中起关键作用。树突状细胞（Dendritic cells，DC）是激活抗肿瘤T细胞应答并维持效应子应答的关键免疫细胞。DC疫苗接种是一种有前景的细胞免疫疗法，其具有促进抗肿瘤免疫应答并通过肿瘤抗原呈递和细胞-细胞通讯改变NSCLC TME组成的潜力。在这里，我们将审查的非小细胞肺癌TME的特点，强调直接与DC相互作用的免疫细胞表型。此外，我们将总结DC疫苗生成的主要临床前和临床方法，并研究有效的DC疫苗接种如何将NSCLC TME转化为持续的抗肿瘤免疫信号传导状态。
Non-small-cell lung cancer (NSCLC) remains one of the leading causes of death worldwide. While NSCLCs possess antigens that can potentially elicit T cell responses, defective tumor antigen presentation and T cell activation hinder host anti-tumor immune responses. The NSCLC tumor microenvironment (TME) is composed of cellular and soluble mediators that can promote or combat tumor growth. The composition of the TME plays a critical role in promoting tumorigenesis and dictating anti-tumor immune responses to immunotherapy. Dendritic cells (DCs) are critical immune cells that activate anti-tumor T cell responses and sustain effector responses. DC vaccination is a promising cellular immunotherapy that has the potential to facilitate anti-tumor immune responses and transform the composition of the NSCLC TME via tumor antigen presentation and cell–cell communication. Here, we will review the features of the NSCLC TME with an emphasis on the immune cell phenotypes that directly interact with DCs. Additionally, we will summarize the major preclinical and clinical approaches for DC vaccine generation and examine how effective DC vaccination can transform the NSCLC TME toward a state of sustained anti-tumor immune signaling.
登录
查看更多内容
影响因子：
7.2
作者：
通讯作者：
--
影响因子：
4.9
作者：
Bosch, Naomi C.;Voll, Reinhard E.;Doerrie, Jan
通讯作者：
Doerrie, Jan
影响因子：
15.9
作者：
Bedoret, Denis;Wallemacq, Hugues;Bureau, Fabrice
通讯作者：
Bureau, Fabrice
影响因子：
3.1
作者：
Burgdorf, Stefan K.;Claesson, Mogens H.;Rosenberg, Jacob
通讯作者：
Rosenberg, Jacob
癌症免疫疗法。树突状细胞疫苗增加了黑色素瘤新抗原特异性T细胞的广度和多样性。
DOI：
10.1126/science.aaa3828
发表时间：
2015-05-15
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Carreno BM;Magrini V;Becker-Hapak M;Kaabinejadian S;Hundal J;Petti AA;Ly A;Lie WR;Hildebrand WH;Mardis ER;Linette GP
通讯作者：
Linette GP