Differential activation of monkey striatal neurons in the early and late stages of procedural learning
Differential activation of monkey striatal neurons in the early and late stages of procedural learning
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DOI：
10.1007/s00221-002-1213-7
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发表时间：
2002-09-01
影响因子：
2
通讯作者：
Lu, XF
中科院分区：
文献类型：
--
作者：
Miyachi, S;Hikosaka, O;Lu, XF
基底神经节是程序性学习的关键结构。为了检查基底神经节参与程序性学习的哪些方面，我们在猴子执行顺序按钮按下任务（2x5 任务）时记录了猴子的纹状体神经元（阶段性活跃神经元），并比较了两种条件之间的神经元活动：（1）学习新序列时和（2）执行过度学习的序列时。在两只猴子中记录的 147 个神经元中，45 个神经元因新序列而被优先激活（新偏好神经元），34 个因过度学习序列而被激活（学习偏好神经元），68 个被非选择性激活（非选择性神经元）。新偏好神经元在“关联”区域[关联纹状体（AS）；尾状核和前连合前的头壳核]，而学习偏好神经元在“感觉运动”区域[感觉运动纹状体（SM）；壳核位于前连合后方]。除了学习依赖性之外，AS 和 SM 神经元在不同的任务周期中被激活：许多 AS 神经元在延迟期间被激活，而 SM 神经元在伸手和按下按钮时被激活更多。这些数据与我们之前的封锁研究的数据一起表明，基底神经节的“关联”和“感觉运动”区域分别优先促进程序性学习的早期和晚期阶段。
The basal ganglia is a key structure for procedural learning. To examine in what aspects of procedural learning the basal ganglia participate, we recorded from striatal neurons (phasically active neurons) in monkeys while the animals were performing a sequential button press task (the 2x5 task) and compared the neuronal activity between two conditions: (1) while learning new sequences and (2) while executing overlearned sequences. Among 147 neurons recorded in two monkeys, 45 neurons were activated preferentially for new sequences (new-preferring neurons), 34 for overlearned sequences (learned-preferring neurons), and 68 were activated non-selectively (non-selective neurons). New-preferring neurons were more abundant in the "association" region [association striatum (AS); caudate nucleus and rostral putamen anterior to the anterior commissure], while the learned-preferring neurons were more abundant in the "sensorimotor" region [sensorimotor striatum (SM); putamen posterior to the anterior commissure]. In addition to the learning dependency, the AS and SM neurons were activated in different task periods: many AS neurons were activated during the delay period, while the SM neurons were more activated with reaching and button presses. These data, together with the data from our previous blockade study, suggest that the "association" and "sensorimotor" regions of the basal ganglia contribute preferentially to the early and late stages of procedural learning, respectively.