Macular choroidal blood flow velocity decreases with regression of acute central serous chorioretinopathy
Macular choroidal blood flow velocity decreases with regression of acute central serous chorioretinopathy
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DOI：
10.1136/bjophthalmol-2012-302349
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发表时间：
2013-06-01
影响因子：
4.1
通讯作者：
Ishida, Susumu
中科院分区：
文献类型：
--
作者：
Saito, Michiyuki;Saito, Wataru;Ishida, Susumu
目的定量评价急性中心性浆液性脉络膜视网膜病变(CSC)黄斑脉络膜血流速度的时程变化。方法回顾性观察20例(21只眼)急性中心性浆液性脉络膜视网膜病变患者，男17例，女3例，平均年龄53.0岁。用激光散斑血流图计算黄斑平均模糊率(MBR)，这是第一次就诊时、3个月和6个月后相对血流速度的指标。结果所有患者术后6个月视网膜下积液完全消退，术后6个月最佳矫正视力(BCVA)较术前有明显提高。在随访期内，平均MBR在3个月和6个月时分别较基线(100%)显著下降至92.8%和82.3%。重要的是，BCVA恢复与MBR降低呈负相关，提示MBR升高可能与视力预后不良有关。多元回归分析显示MBR与眼球灌注压无显著相关性。结论黄斑脉络膜血流速度减慢与CSC的消退同步，提示脉络膜血流增高在急性CSC发病机制中的有效性。
Aim To quantitatively evaluate the time course of macular choroidal blood flow velocity in acute central serous chorioretinopathy (CSC).Methods This retrospective observational case series included 21 eyes of 20 patients (17 men, 3 women; mean age, 53.0 years) with treatment-naive acute CSC. Laser speckle flowgraphy was performed to calculate macular mean blur rate (MBR), an indicator of relative blood flow velocity at the first visit, 3 and 6 months thereafter. Changes in average MBR values were compared with visual improvement at 6 months.Results Subretinal fluid completely resolved in all eyes within 6 months, while best-corrected visual acuity (BCVA) significantly improved at 6 months compared to the initial BCVA. During the follow-up period, the average MBR significantly decreased to 92.8% and 82.3% at 3 and 6 months, respectively, against baseline (100%). Importantly, there was a negative correlation between the BCVA recovery and the MBR decrease, showing the possible association of MBR increase with poor visual prognosis. Multiple regression analysis demonstrated no significant correlation between MBR and ocular perfusion pressure.Conclusions These results indicate that macular choroidal blood flow velocity decreases concurrently with regression of CSC, suggesting a validity of choroidal blood flow elevation in the pathogenesis of acute CSC.