The Danish 1905 cohort: A genetic-epidemiological nationwide survey
The Danish 1905 cohort: A genetic-epidemiological nationwide survey
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DOI：
10.1177/089826430101300102
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发表时间：
2001-02-01
影响因子：
2.8
通讯作者：
Christensen, K
中科院分区：
文献类型：
--
作者：
Nybo, H;Gaist, D;Christensen, K
目的：作者研究了九十多岁老人，这是一个快速增长的年龄组，其认知和身体能力尚未得到系统的调查。所有1905年出生的丹麦人被邀请参加一项基于家庭的2小时多维访谈，包括认知和身体表现测试以及DNA连接，由非专业访谈者进行。采用基于人群的登记来评估代表性。结果：共有2262名参与者，其中1632人（72%）提供了DNA样本。参与者和非参与者在婚姻状况、机构和住院模式方面具有高度可比性，但男性和农村地区居民更有可能参与。调查开始六个月后，7.2%的参与者和11.8%的非参与者已经死亡。讨论：尽管众所周知，在高龄老人中进行调查存在困难，但还是有可能在全国范围内进行一项调查，包括收集DNA，调查对象是2000多名相当未经挑选的90多岁老人，使用的是外行采访者。
Objectives: The authors studied nonagenarians, a rapidly growing age group whose cognitive and physical abilities have yet to be investigated systematically. All Danes born in 1905 were invited to participate in a home-based 2-hour multidimensional interview, including cognitive and physical performance tests and conection of DNA, carried out by lay interviewers. Population-based registers were used to evaluate representativeness. Results: There were 2,262 participants, A total of 1,632 (72%) gave a DNA sample. Participants and nonparticipants were highly comparable with regard to marital status, institutionalization, and hospitalization patterns, but men and rural area residents were more likely to participate. Six months after the survey began, 7.2% of the participants and 11.8% of the nonparticipants had died. Discussion: Despite the known difficulties of conducting surveys among the extremely old, it was possible to conduct a nationwide survey, including collection of DNA, among more than 2,000 fairly nonselected nonagenarians using lay interviewers.