Streptococcus pneumoniae serotypes involved in children with pleural empyemas in France
Streptococcus pneumoniae serotypes involved in children with pleural empyemas in France
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DOI：
10.1016/j.arcped.2006.12.010
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发表时间：
2007-03-01
影响因子：
1.8
通讯作者：
Delacourt, C.
中科院分区：
文献类型：
--
作者：
Bekri, H.;Cohen, R.;Delacourt, C.
有人认为，儿童脓胸的发病率在过去几年中在法国增加，但没有明确的解释。肺炎链球菌是造成绝大多数细菌学记录病例的原因。七价肺炎球菌结合疫苗预防胸腔积脓的可能性取决于疫苗中存在的特定肺炎球菌血清群与导致脓胸的血清群之间的适当性。- 我们回顾性收集了2002年12月至2004年2月在国家肺炎球菌参考中心登记的胸腔积脓病例。纳入30名儿童，年龄4.1 ± 3.3（SD）岁。- 鉴定了10个特异性血清群：1、3、5、613、717、9V、14、18 C、19 A和23 F。血清群19A和1是2个主要血清群，占病例的50%。所有感染血清型19A的儿童均小于5岁，而在大于5岁的儿童中，80%的脓胸中发现了阴囊1型。在30例患者中，20例（69%）感染了结合疫苗中未包括的性分型。- 因此，这些结果限制了七价肺炎球菌结合疫苗对儿童胸腔积脓频率的潜在影响。(c)2007年，Elsevier Masson SAS。图斯所有权保留。
It has been suggested that the incidence of childhood empyema have increased during the last years in France without clear explanation. Streptococcus pneumoniae is responsible for the vast majority of bacteriological documented cases. Potential prevention of pleural empyemas by the heptavalent pneumococcal conjugate vaccine is dependent on adequation between specific pneumococcal serogroups present in vaccine and those responsible for empyemas.Material and methods. - We retrospectively collected cases of pleural empyemas registered at the National Reference Center for pneumococci (December 2002 to February 2004). Thirty children, aged 4.1 +/- 3.3 (SD) years, were included.Results. - Ten specific serogroups were identified: 1, 3, 5, 613, 717, 9V, 14, 18C, 19A, and 23F. Serogroups 19A and 1 were the 2 dominant serogroups and represented 50% of cases. All children infected with serotype 19A were younger than 5 years, whereas scrotype 1 was identified in 80% of empyemas in children older than 5 years. Among the 30 patients enrolled, 20 (69%) were infected with erotypes not included in the conjugate vaccine.Conclusion. - These results thus limit the potential impact of the heptavalent pneumococcal conjugate vaccine on the frequency of pleural empyemas in children. (c) 2007 Elsevier Masson SAS. Tous droits reserves.