Aspirin is an effective pretreatment for exercise in multiple sclerosis: A double-blind randomized controlled pilot trial
Aspirin is an effective pretreatment for exercise in multiple sclerosis: A double-blind randomized controlled pilot trial
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DOI：
10.1177/1352458517739138
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发表时间：
2018-10-01
影响因子：
5.8
通讯作者：
Stein, Joel
中科院分区：
文献类型：
--
作者：
Leavitt, Victoria M.;Blanchard, Adam R.;Stein, Joel
运动对多发性硬化症（MS）患者有益，但运动引起的过热对许多人来说是一种威慑。我们进行了一项双盲交叉设计安慰剂对照试验，以阿司匹林增加疲劳时间（TTE）并减少运动引起的体温升高。共有12例患者参与。在入组时，12人中有8人报告在运动时热敏。在服用了650毫克阿司匹林或安慰剂后，参与者进行了下肢循环测力仪运动测试。与安慰剂相比，服用阿司匹林后TTE增加：t(11) = 2.405, p = 0.035 （Cohen’s d = 1.45）。在热敏患者中，使用乙酰水杨酸（ASA）运动后的体温升高降低了56%，尽管有限的功率排除了统计学意义。阿司匹林可能是多发性硬化症运动的有效预处理。
Exercise benefits multiple sclerosis (MS) patients, but exercise-induced overheating is a deterrent for many. We conducted a double-blind crossover-design placebo-controlled pilot of aspirin to increase time-to-exhaustion (TTE) and reduce exercise-induced body temperature increase. A total of 12 patients participated. At enrollment, 8 of 12 reported heat sensitivity during exercise. After 650 mg of aspirin or placebo, participants performed lower body cycle ergometer exercise test. TTE increased after aspirin compared to placebo: t(11) = 2.405, p = 0.035 (Cohen's d = 1.45). Body temperature increase after exercise with acetylsalicylic acid (ASA) was reduced by 56% in heat-sensitive patients, although limited power precluded statistical significance. Aspirin may represent an effective pretreatment for exercise in MS.