Understanding the burst release phenomenon: toward designing effective nanoparticulate drug-delivery systems
Understanding the burst release phenomenon: toward designing effective nanoparticulate drug-delivery systems
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DOI：
10.4155/tde-2020-0099
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发表时间：
2021-01-01
影响因子：
4.2
通讯作者：
Bhattacharjee, Sourav
中科院分区：
文献类型：
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作者：
Bhattacharjee, Sourav
无论是在体外还是在体内，在短时间内将相当一部分有效载荷释放到释放介质中的胶囊药物的突然释放仍然是翻译的一个挑战。这种不可预测和不受控制的释放往往是不受欢迎的，特别是从开发缓释制剂的角度来看。此外，有效载荷的快速释放会扰乱最佳释放动力学。这一描述致力于理解在纳米载体中注意到的突发释放，并调查其原因。还研究了解释这种不及时发布的各种数学模型，包括它们的优点和缺点。最后，该报告回顾了目前限制纳米载体突发释放的技术，并通过减少此类事件的发生，确定了蕴藏着富有成效的翻译潜力的未来方向的优先顺序。
Burst release of encapsulated drug with release of a significant fraction of payload into release medium within a short period, both in vitro and in vivo, remains a challenge for translation. Such unpredictable and uncontrolled release is often undesirable, especially from the perspective of developing sustained-release formulations. Moreover, a brisk release of the payload upsets optimal release kinetics. This account strives toward understanding burst release noticed in nanocarriers and investigates its causes. Various mathematical models to explain such untimely release were also examined, including their strengths and weaknesses. Finally, the account revisits current techniques of limiting burst release from nanocarriers and prioritizes future directions that harbor potential of fruitful translation by reducing such occurrences.