Clinical features of chronic cluster headache based on the third edition of the International Classification of Headache Disorders: A prospective multicentre study
Clinical features of chronic cluster headache based on the third edition of the International Classification of Headache Disorders: A prospective multicentre study
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DOI：
10.1371/journal.pone.0221155
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发表时间：
2019-08-26
期刊：
影响因子：
3.7
通讯作者：
Chung, Chin-Sang
中科院分区：
文献类型：
--
作者：
Cho, Soo-Jin;Lee, Mi Ji;Chung, Chin-Sang
国际头痛疾病分类第三版（ICHD-3）将慢性丛集性头痛（CCH）的缓解期标准由< 1个月修订为< 3个月。然而，目前基于ICHD-3标准的CCH临床特征信息有限。本研究的目的是调查CCH的临床特征的基础上ICHD-3使用的数据从韩国丛集性头痛登记（KERO）。KARNING是一项多中心前瞻性登记研究，纳入了来自15家医院的丛集性头痛（CH）患者。在250名CH参与者中，分别有12名和176名参与者被归类为CCH和阵发性丛集性头痛（ECH）。在12例CCH患者中，6例（50%）缓解期< 1个月，其余6例（50%）缓解期为1-3个月。6名参与者从CH发作时就患有CCH，而在其他6名参与者中，CCH是从ECH演变而来的。CCH受试者有较晚的CH发病年龄，在CH发病后较长的时间间隔后发展的条件，并有更多的偏头痛和更少的鼻塞和/或鼻出血比ECH受试者。缓解期< 1个月的CCH与缓解期1-3个月的CCH临床特征除发作总次数外无显著性差异。与ECH患者相比，从ECH演变而来的CCH患者目前吸烟更多，昼夜节律性更少。总之，当使用修订的ICHD-3标准时，患有CCH的受试者数量增加了一倍。应用ICHD前、后两版标准进行比较，大部分CCH的临床特征无差异。CCH的某些临床特征与ECH不同，吸烟可能在CH慢性化中起作用。
The criterion for the remission period of chronic cluster headache (CCH) was recently revised from < 1 month to < 3 months in the third edition of the International Classification of Headache Disorders (ICHD-3). However, information on the clinical features of CCH based on the ICHD-3 criteria is currently limited. The present study aimed to investigate the clinical features of CCH based on ICHD-3 using data from the Korean Cluster Headache Registry (KCHR). The KCHR is a multicentre prospective registry of patients with cluster headache (CH) from 15 hospitals. Among the 250 participants with CH, 12 and 176 participants were classified as having CCH and episodic cluster headache (ECH), respectively. Among 12 participants with CCH, 6 (50%) had remission periods of < 1 month, and the remaining 6 (50%) had a remission period of 1-3 months. Six participants had CCH from the time of onset of CH, and in the other 6 participants, CCH evolved from ECH. CCH subjects had later age of onset of CH, developed the condition after a longer interval after CH onset, and had more migraine and less nasal congestion and/or rhinorrhoea than ECH subjects. Clinical features of CCH with remission periods < 1 month were not significantly different from those of CCH with remission periods of 1-3 months, except for the total number of bouts. More current smoking and less diurnal rhythmicity were observed in participants with CCH evolved from ECH compared to those with ECH. In conclusion, the number of subjects with CCH doubled when the revised ICHD-3 criteria were used. Most of clinical characteristics of CCH did not differ when the previous and current version of ICHD was applied and compared. Some clinical features of CCH were different from those of ECH, and smoking may have a role in CH chronification.