Metformin Actions on the Liver: Protection Mechanisms Emerging in Hepatocytes and Immune Cells against NASH-Related HCC.
Metformin Actions on the Liver: Protection Mechanisms Emerging in Hepatocytes and Immune Cells against NASH-Related HCC.
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代谢物对肝脏的作用：肝细胞和免疫细胞中出现的针对NASH相关HCC的保护机制。
DOI：
10.3390/ijms22095016
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发表时间：
2021-05-09
影响因子：
5.6
通讯作者：
Xiao H
中科院分区：
文献类型：
--
作者：
Zhang Y;Wang H;Xiao H
非酒精性脂肪性肝病（NAFLD）与肥胖和2型糖尿病（T2DM）的全球流行密切相关。值得注意的是，NAFLD可以从最轻微的单纯脂肪变性发展为非酒精性脂肪性肝炎（NASH），增加肝细胞癌（HCC）的风险，HCC是一种预后不理想的恶性肿瘤，在美国和其他发达国家发病率上升，可能是由于NAFLD的流行。人类流行病学研究和动物模型临床前研究显示，二甲双胍作为治疗2型糖尿病的一线药物，已被认为可以降低包括HCC在内的几种癌症的风险，并预防nash相关的HCC。本文综述了nash相关HCC的发病机制以及二甲双胍抑制nash相关HCC发生和发展的机制。由于免疫细胞在肝脏稳态和发病机制中的功能作用在肝脏恶性肿瘤的抗癌治疗中越来越受到重视，我们讨论了二甲双胍在肝细胞中的传统靶点以及最近定义的二甲双胍对免疫细胞的作用。
Nonalcoholic fatty liver disease (NAFLD) is strongly linked to the global epidemic of obesity and type 2 diabetes mellitus (T2DM). Notably, NAFLD can progress from the mildest form of simple steatosis to nonalcoholic steatohepatitis (NASH) that increases the risk for hepatocellular carcinoma (HCC), which is a malignancy with a dismal prognosis and rising incidence in the United States and other developed counties, possibly due to the epidemic of NAFLD. Metformin, the first-line drug for T2DM, has been suggested to reduce risks for several types of cancers including HCC and protect against NASH-related HCC, as revealed by epidemical studies on humans and preclinical studies on animal models. This review focuses on the pathogenesis of NASH-related HCC and the mechanisms by which metformin inhibits the initiation and progression of NASH-related HCC. Since the functional role of immune cells in liver homeostasis and pathogenesis is increasingly appreciated in developing anti-cancer therapies on liver malignancies, we discuss both the traditional targets of metformin in hepatocytes and the recently defined effects of metformin on immune cells.
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影响因子：
29.7
作者：
Davis BK;Wen H;Ting JP
通讯作者：
Ting JP
影响因子：
--
作者：
Brunner SM;Itzel T;Rubner C;Kesselring R;Griesshammer E;Evert M;Teufel A;Schlitt HJ;Fichtner-Feigl S
通讯作者：
Fichtner-Feigl S
二甲双胍通过抑制肿瘤相关巨噬细胞的 M2 样极化来预防癌症转移
影响因子：
--
作者：
Ding L;Liang G;Yao Z;Zhang J;Liu R;Chen H;Zhou Y;Wu H;Yang B;He Q
通讯作者：
He Q
影响因子：
5.1
作者：
Brar G;Greten TF;Graubard BI;McNeel TS;Petrick JL;McGlynn KA;Altekruse SF
通讯作者：
Altekruse SF
影响因子：
9.8
作者：
Buzzetti, Elena;Pinzani, Massimo;Tsochatzis, Emmanuel A.
通讯作者：
Tsochatzis, Emmanuel A.