Possible association between long anterior lens zonules and plateau iris configuration.
Possible association between long anterior lens zonules and plateau iris configuration.
复制标题
长前晶状体小带和平台虹膜结构之间可能存在关联。
DOI：
10.1097/ijg.0b013e31815c3b04
复制
发表时间：
2008
影响因子：
2
通讯作者：
Moroi,SayokoE
中科院分区：
文献类型：
--
作者：
Roberts,DanielK;Ayyagari,Radha;Moroi,SayokoE
PurposeTo report plateau iris configuration (PIC) in subjects who have the long anterior zonule (LAZ) clinical trait.MethodsTwo elderly African American males who exhibited LAZ and had partial appositional angle closure persisting after laser iridotomy were imaged with high-resolution ultrasonography to examine for PIC. A third elderly LAZ subject who had narrow angles without closure was also imaged for PIC. Each subject was tested for a serine 163 arginine mutation (S163R) C1q tumor necrosis factor-related protein 5 gene (C1QTNF5/CTRP5) mutation, which may be associated with the LAZ phenotype.ResultsAll 3 LAZ subjects also had PIC, an unlikely association due to chance alone. None carried the S163R CTRP5 mutation.ConclusionsLAZ and PIC may have association and require study because LAZ might be a useful indicator for an increased likelihood of PIC and risk of angle closure. Mutation other than CTRP5 S163R should also be considered for the LAZ trait, which could be an important phenotypic marker in genetic studies.
