A logic-based dynamic modeling approach to explicate the evolution of the central dogma of molecular biology
A logic-based dynamic modeling approach to explicate the evolution of the central dogma of molecular biology
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DOI：
10.1371/journal.pone.0189922
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发表时间：
2017-12-21
期刊：
影响因子：
3.7
通讯作者：
Mirzaie, Mehdi
中科院分区：
文献类型：
--
作者：
Jafari, Mohieddin;Ansari-Pour, Naser;Mirzaie, Mehdi
分子生物学的中心法则(CD)的引入时代已经过去了近半个世纪。这一生物学公理已经发展起来，目前看起来更加复杂。在这项研究中，我们通过在CD信息流中添加更多的物种来修改CD，并在动态框架内使用布尔网络在其现有版本和1965年版本的基础上以数学方式表达CD。我们表明，DOGMA的增强现在不仅需要更高水平的复杂性，而且还表现出更高水平的稳健性，因此与生物系统的性质更加一致。利用这种数学建模方法，我们提出了一种基于逻辑的表达我们的分子生物学概念观点。最后，我们表明，这样的生物学概念可以使用基于逻辑的方法转换为动态数学模型，因此可以作为改进生物学静态概念模型的框架。
It is nearly half a century past the age of the introduction of the Central Dogma (CD) of molecular biology. This biological axiom has been developed and currently appears to be all the more complex. In this study, we modified CD by adding further species to the CD information flow and mathematically expressed CD within a dynamic framework by using Boolean network based on its present-day and 1965 editions. We show that the enhancement of the Dogma not only now entails a higher level of complexity, but it also shows a higher level of robustness, thus far more consistent with the nature of biological systems. Using this mathematical modeling approach, we put forward a logic-based expression of our conceptual view of molecular biology. Finally, we show that such biological concepts can be converted into dynamic mathematical models using a logic-based approach and thus may be useful as a framework for improving static conceptual models in biology.