The C-terminus of murine S100A9 inhibits hyperalgesia and edema induced by jararhagin
The C-terminus of murine S100A9 inhibits hyperalgesia and edema induced by jararhagin
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DOI：
10.1016/j.peptides.2003.12.008
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发表时间：
2004-01-01
期刊：
影响因子：
3
通讯作者：
Giorgi, R
中科院分区：
文献类型：
--
作者：
Dale, CS;Gonçalves, LRC;Giorgi, R
研究了与鼠S100 A9（mS 100 A9 p）的C-末端相同的合成肽（H-92-G（110））对由jararhagin或木瓜蛋白酶在大鼠爪中诱导的痛觉过敏和水肿的作用。mS 100 A9 p不仅能逆转jarararhagin引起的痛敏和水肿，而且在最高浓度时也能产生抗伤害作用。mS 100 A9 p抑制jararhagin诱导的出血及其水解活性。这些数据表明，mS 100 A9 p可能通过抑制贾拉金催化活性来阻断贾拉金诱导的痛觉过敏和水肿，因为木瓜蛋白酶诱导的痛觉过敏和水肿不受mS 100 A9 p的抑制。(C)2004年爱思唯尔公司All rights reserved.
The effect of a synthetic peptide (H-92-G(110)) identical to the C-terminus of murine S100A9 (mS100A9p) was investigated on hyperalgesia and edema induced by either jararhagin or papain in the rat paw. mS100A9p not only reverted hyperalgesia and edema induced by jararhagin, but also the highest concentration induced antinociception. Hemorrhage induced by jararhagin and its hydrolytic activity were inhibited by mS100A9p. These data suggest that mS100A9p might block jararhagin-induced hyperalgesia and edema by inhibiting jararhagin catalytic activity, since papain-induced hyperalgesia and edema were not inhibited by mS100A9p. (C) 2004 Elsevier Inc. All rights reserved.