Cytomegalovirus is associated with reduced telomerase activity in the Whitehall II cohort
Cytomegalovirus is associated with reduced telomerase activity in the Whitehall II cohort
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DOI：
10.1016/j.exger.2013.01.016
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发表时间：
2013-04-01
影响因子：
3.9
通讯作者：
Aiello, Allison E.
中科院分区：
文献类型：
--
作者：
Dowd, Jennifer B.;Bosch, Jos A.;Aiello, Allison E.
端粒长度和端粒酶活性作为细胞衰老的标志物受到越来越多的关注，但这些标志物的个体间差异的决定因素还不完全清楚。巨细胞病毒（CMV）感染可能对端粒和端粒酶动力学特别重要，因为其对外周血淋巴细胞组成的显著影响，即，增加以较短的端粒长度（TL）和较低的端粒酶活性（TA）为特征的高度分化的T细胞的数量和比例。然而，CMV感染与白细胞TL和TA之间的可能关系尚未在体内得到很好的研究。本研究检测了来自白厅II队列的434名健康个体（年龄53-76岁）的CMV血清阳性和CMV IgG抗体与白细胞（TL）和（TA）的相关性。阳性CMV血清状态与女性TA较低显著相关，而较高的CMV IgG抗体水平与总体样本中TA较低相关。然而，CMV血清阳性和CMV IgG抗体水平（反映亚临床再激活）之间的血清阳性与TL显着相关。这些协会是强大的调整年龄，就业等级，BMI和吸烟状况。结果表明，CMV血清阳性和亚临床再激活预测TA较低。未来的纵向研究应该测试CMV与较低TA的关联是否有助于随着时间的推移加速端粒缩短。(C)2013 Elsevier Inc. All rights reserved.
Telomere length and telomerase activity have received increased attention as markers of cellular aging, but the determinants of inter-individual variation in these markers are incompletely understood. Cytomegalovirus (CMV) infection may be particularly important for telomere and telomerase dynamics due to its dramatic impact on peripheral blood lymphocyte composition, i.e., increasing the number and proportions of highly differentiated T cells that are characterized by shorter telomere length (TL) and lowered telomerase activity (TA). However, the possible relationship between CMV infection and leukocyte TL and TA has not been well-examined in vivo. This study examined the associations of CMV seropositivity and CMV IgG antibodies with leukocyte (TL) and (TA) in a sample of 434 healthy individuals (ages 53-76) from the Whitehall II cohort. Positive CMV serostatus was significantly associated with lower TA among women, and higher CMV IgG antibody levels were associated with lower TA in the overall sample. However, neither CMV seropositivity nor CMV IgG antibody levels (reflecting subclinical reactivation) among the seropositive were significantly associated with TL. These associations were robust to adjustment for age, employment grade, BMI, and smoking status. The results demonstrate that CMV seropositivity and subclinical reactivation predict lower TA. Future longitudinal studies should test whether the association of CMV with lower TA contributes to accelerated telomere shortening over time. (C) 2013 Elsevier Inc. All rights reserved.