A trial of topical acyclovir in genital herpes simplex virus infections.
A trial of topical acyclovir in genital herpes simplex virus infections.
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局部阿昔洛韦治疗生殖器单纯疱疹病毒感染的试验。
DOI：
10.1056/nejm198206033062201
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发表时间：
1982
期刊：
影响因子：
--
通讯作者：
Holmes,KK
中科院分区：
文献类型：
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作者：
Corey,L;Nahmias,AJ;Guinan,ME;Benedetti,JK;Critchlow,CW;Holmes,KK
77 名首次发作生殖器疱疹患者和 111 名复发性生殖器疱疹患者参加了一项双盲试验，比较外用阿昔洛韦与安慰剂（聚乙二醇软膏）。在接受阿昔洛韦治疗的首发原发性生殖器疱疹患者中，病毒脱落的平均持续时间（4.1天）和治疗开始时出现的病变完成结痂的时间（7.1天）均短于安慰剂接受者（分别为7.0天和10.5天）（P<0.05）。接受阿昔洛韦治疗的复发性疱疹患者的病毒脱落持续时间比安慰剂接受者短（0.95 天与 1.90 天）（P = 0.03）。在复发性疱疹患者中，阿昔洛韦缩短了男性皮损结痂的时间，但对女性的症状或愈合时间没有影响。外用阿昔洛韦可缩短病毒脱落的持续时间并加速某些生殖器单纯疱疹病毒感染的愈合。 （新英格兰医学杂志，1982；306：1313-9）。
Seventy-seven patients with first episodes of genital herpes and 111 with recurrent episodes were enrolled in a double-blind trial comparing topical acyclovir with a placebo (polyethylene glycol ointment). Among acyclovir-treated patients with first-episode primary genital herpes, the mean duration of viral shedding (4.1 days) and the time to complete crusting of lesions present at the initiation of therapy (7.1 days) were shorter than among placebo recipients (7.0 and 10.5 days, respectively) (P<0.05). Acyclovir-treated patients with recurrent herpes had a shorter duration of viral shedding than placebo recipients (0.95 vs. 1.90 days) (P = 0.03). Among the patients with recurrent herpes, acyclovir reduced the time to crusting of lesions in men but had no effect on the symptoms or healing times in women. Topical acyclovir shortens the duration of viral shedding and accelerates healing of some genital herpes simplex virus infections. (N Engl J Med. 1982; 306:1313–9).