Induced and natural regulatory T cells in the development of inflammatory bowel disease.
Induced and natural regulatory T cells in the development of inflammatory bowel disease.
复制标题
DOI：
10.1097/mib.0b013e318281f5a3
复制
发表时间：
2013-07
影响因子：
4.9
通讯作者：
Williams CB
中科院分区：
文献类型：
--
作者：
Mayne CG;Williams CB
The mucosal immune system mediates contact between the host, and the trillions of microbes that symbiotically colonize the gastrointestinal tract. Failure to tolerate the antigens within this “extended self” can result in inflammatory bowel disease (IBD). Within the adaptive immune system, the most significant cells modulating this interaction are Foxp3+ regulatory T (Treg) cells. Treg cells can be divided into two primary subsets: “natural” Treg (nTreg) cells, and “adaptive” or “induced” Treg (iTreg). Recent research suggests that these subsets serve to play both independent and synergistic roles in mucosal tolerance. Studies from both mouse models and human patients suggest defects in Treg cells can play distinct causative roles in IBD. Numerous genetic, microbial, nutritional, and environmental factors that associate with IBD may also affect Treg cells. In this review we summarize the development and function of Treg cells, and how their regulatory mechanisms may fail, leading to a loss of mucosal tolerance. We discuss both animal models and studies of IBD patients suggesting Treg cell involvement in IBD, and consider how Treg cells may be used in future therapies.
