Study of 7 Cases of Giant Cell Tumor of Soft Tissue.
Study of 7 Cases of Giant Cell Tumor of Soft Tissue.
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DOI：
10.1016/s0377-1237(06)80056-0
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发表时间：
2006-04-01
期刊：
影响因子：
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通讯作者：
Rappai, T J
中科院分区：
文献类型：
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作者：
Chand, Kailash;Bhardwaj, R K;Rappai, T J
背景技术背景：原发性软组织巨细胞瘤是一种独特的，但不常见的一组肿瘤的形态学相同的骨巨细胞tumor.METHODS：7例无痛生长的软组织肿块，没有附着到下面的骨，被确定在一个四年的回顾性研究，从两个区医院的武装部队。这些病变的组织学检查显示多核巨细胞与单核细胞混合。所有患者均行手术切除，随访复发情况。结果：男5例，女2例，年龄18 ~ 56岁。除1例外，所有病变均为浅表、局限性和累及四肢。良性和恶性病变之间的组织学转变，目前只有一个3个月后复发的7例患者，她不得不再次手术。结论：原发性软组织巨细胞瘤多表现为无痛性肿块，需与其他富含巨细胞的软组织肿瘤鉴别。如果病变被充分切除，良性临床过程是预期的。它的生物学行为具有低恶性潜力是公认的，但这是无法预测的，转移确实很少发生。
BACKGROUND: Primary giant cell tumour of soft tissues is a distinct but uncommon group of neoplasms morphologically identical to osseous giant cell tumor.METHODS: 7 patients with painless growing soft tissue mass, having no attachment to underlying bone, were identified in a four years retrospective study from two zonal hospitals of armed forces. Histopathology of these lesions revealed admixture of multinucleated giant cell with mononuclear cells. All patients were treated by surgical resection and followed up for recurrence. Results : There were 5 male and 2 female patients in the age group of 18 to 56 years. All lesions were superficial, circumscribed and involved extremities except one. Histologic transition between benign and malignant lesion was present in only one of the 7 patients that recurred after three months of surgery for which she had to be operated again. 2 of our 7 cases were lost in follow up.CONCLUSION: Primary giant cell tumour of soft tissues usually present as a painless mass and needs to be differentiated from other giant cell rich soft tissue tumors. Benign clinical course is expected if the lesion is excised adequately. Its biological behaviour to have low malignant potential is recognized; but this cannot be predicted and metastasis does occur rarely.