Tractography-based parcellation of the human left inferior parietal lobule
Tractography-based parcellation of the human left inferior parietal lobule
复制标题
基于纤维束成像的人类左顶下小叶分割
DOI：
10.1016/j.neuroimage.2012.07.045
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发表时间：
2012-11-01
期刊：
影响因子：
5.7
通讯作者：
Jiang, Tianzi
中科院分区：
文献类型：
--
作者：
Wang, Jiaojian;Fan, Lingzhong;Jiang, Tianzi
下顶叶（IPL）是一个功能和解剖异质性的区域。关于该区域的解剖连通性和分割的许多信息是从非人类灵长类动物的组织学研究中获得的。然而，这些非人类灵长类动物的发现是否适用于人类顶叶下小叶，特别是显示了从灵长类动物到人类的相当大进化证据的左顶叶下小叶，尚不清楚。本研究采用弥散MRI对人类左顶叶下小叶的解剖连通性进行了研究。利用边缘加权质心voronoi镶嵌的谱聚类算法，搜索所有左侧下顶叶体素与大脑其他部分的概率连通性分布的区域变化，确定了左侧下顶叶中具有不同连通性特性的六个亚区。与细胞结构的发现一致，左侧边缘上回有4个亚区，左侧角回有2个亚区。通过基于meta分析的靶法和基于体素的全脑解剖和功能连通性分析计算，左顶叶下小叶各亚区具体的连通性模式得到了各亚区解剖和功能连通性特性的支持。提出的人类左顶叶下小叶的分割方案和每个子区域的最大概率图可能有助于未来对该脑区域进行更详细的研究。(C) 2012爱思唯尔公司版权所有。
The inferior parietal lobule (IPL) is a functionally and anatomically heterogeneous region. Much of the information about the anatomical connectivity and parcellation of this region was obtained from histological studies on non-human primates. However, whether these findings from non-human primates can be applied to the human inferior parietal lobule, especially the left inferior parietal lobule, which shows evidence of considerable evolution from primates to humans, remains unclear. In this study, diffusion MRI was employed to investigate the anatomical connectivities of the human left inferior parietal lobule. Using a new algorithm, spectral clustering with edge-weighted centroidal voronoi tessellations, to search for regional variations in the probabilistic connectivity profiles of all left inferior parietal lobule voxels with all the rest of the brain identified six subregions with distinctive connectivity properties in the left inferior parietal lobule. Consistent with cytoarchitectonic findings, four subregions were found in the left supramarginal gyrus and two subregions in the left angular gyrus. The specific connectivity patterns of each subregion of the left inferior parietal lobule were supported by both the anatomical and functional connectivity properties for each subregion, as calculated by a meta-analysis-based target method and by voxel-based whole brain anatomical and functional connectivity analyses. The proposed parcellation scheme for the human left inferior parietal lobule and the maximum probability map for each subregion may facilitate more detailed future studies of this brain area. (C) 2012 Elsevier Inc. All rights reserved.