Role of Neutrophils in Systemic Vasculitides.
Role of Neutrophils in Systemic Vasculitides.
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中性粒细胞在全身血管增生中的作用。
DOI：
10.3389/fimmu.2020.619705
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发表时间：
2020
影响因子：
7.3
通讯作者：
Lood C
中科院分区：
文献类型：
--
作者：
Michailidou D;Mustelin T;Lood C
中性粒细胞和中性粒细胞胞外陷阱 (NET) 是许多自身免疫性疾病（包括血管炎）的发病机制。尽管中性粒细胞和 NET 可以作为抗中性粒细胞胞浆抗体 (ANCA) 相关性血管炎中自身抗体的自身抗原来源，从而破坏自身耐受性，并在驱动自身免疫反应中发挥关键作用，但中性粒细胞和 NET 在大血管血管炎（包括巨细胞动脉炎 (GCA)）中的作用尚不清楚。在这篇综述中，我们总结了目前对中性粒细胞介导的中小血管血管炎病理学分子机制的见解，并提供了中性粒细胞和NETs如何参与大血管血管炎（一种发病机制尚不清楚的罕见疾病实体）的潜在转化视角。
Neutrophils and neutrophil extracellular traps (NETs) contribute to the pathogenesis of many autoimmune diseases, including vasculitis. Though neutrophils, and NETs, can break self-tolerance by being a source of autoantigens for autoantibodies in anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis, playing a key role in driving the autoimmune response, the role of neutrophils and NETs in large vessel vasculitis, including giant cell arteritis (GCA), is not well understood. In this review, we summarize the current insight into molecular mechanisms contributing to neutrophil-mediated pathology in small and medium vessel vasculitis, as well as provide potential translational perspectives on how neutrophils, and NETs, may partake in large vessel vasculitis, a rare disease entity of unclear pathogenesis.