HLA-G expression in extravillous trophoblasts is an intrinsic property of cell differentiation: a lesson learned from ectopic pregnancies
HLA-G expression in extravillous trophoblasts is an intrinsic property of cell differentiation: a lesson learned from ectopic pregnancies
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DOI：
10.1093/molehr/6.6.535
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发表时间：
2000-06-01
影响因子：
4
通讯作者：
Yagel, S
中科院分区：
文献类型：
--
作者：
Goldman-Wohl, DS;Ariel, I;Yagel, S
人类白细胞抗原(人类白细胞抗原)-G是一种主要的组织相容性基因，几乎只在母胎界面的绒毛外滋养细胞中表达。人类白细胞抗原-G可能在保护胎儿免受母体自然杀伤细胞攻击方面发挥作用。绒毛外滋养细胞侵入蜕膜和母体螺旋动脉。调节人类白细胞抗原-G的细胞特异性表达的因素尚不清楚。在这项研究中，我们询问了在异位妊娠中，在正常细胞环境之外发育的绒毛外滋养层细胞是否表达了人类白细胞抗原-G。由于所有的异位妊娠都是在没有蜕膜的情况下植入的，所以我们也用植入性胎盘作为实验对照，我们发现13例异位标本的绒毛外滋养细胞中都有人类白细胞抗原-G的mRNA和蛋白表达。植入性胎盘(发育时无基底层蜕膜，因此附着于子宫肌层)也表达了人类白细胞抗原-G的基因和蛋白。这些结果表明，HLA-G的表达是以细胞自主的方式诱导的，而不是由适当的环境线索决定的。
Human leukocyte antigen (HLA)-G is a major histocompatibility gene expressed almost exclusively in extravillous trophoblasts at the fetal-maternal interface. HLA-G may play a role in protecting the fetus from attack by the maternal natural killer cells. The extravillous trophoblasts invade the decidua and maternal spiral arteries. The factors which regulate the cell-specific expression of HLA-G are unknown. In this study we asked if HLA-G is expressed in extravillous trophoblasts that develop outside of their normal cellular environment, as in the case of ectopic pregnancies. Since all ectopic pregnancies implant in the absence of underlying decidua we also used a placenta accreta as an experimental control, We found that HLA-G mRNA and protein were expressed in the extravillous trophoblasts in the 13 ectopic specimens studied. In a case of placenta accreta (which develops without decidua basalis and is therefore adherent to the underlying myometrium), HLA-G mRNA and protein were also expressed. These results suggest that HLA-G expression is induced in a cell autonomous manner rather than determined by appropriate environmental cues.