Urgent Proton Beam Therapy With Interinstitutional Transfer for Patients With Intracranial Rhabdomyosarcoma: Report of 3 Cases.
Urgent Proton Beam Therapy With Interinstitutional Transfer for Patients With Intracranial Rhabdomyosarcoma: Report of 3 Cases.
复制标题
颅内横纹肌肉瘤患者紧急质子束治疗并跨机构转移：3 例报告。
DOI：
10.1097/mph.0000000000001620
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发表时间：
2020
期刊：
影响因子：
--
通讯作者：
Takada H
中科院分区：
文献类型：
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作者：
Inaba M;Nakao T;Hosaka S;Suzuki R;Fukushima H;Yamaki Y;Saito T;Sakashita S;Noguchi M;Minami M;Masumoto T;Mizumoto M;Sakurai H;Fukushima T;Takada H
近年来，在脑膜旁横纹肌肉瘤病例中，报告了一些使用质子束治疗减轻影响重要颅器官的不良事件的病例。然而，很少有报道描述使用质子束治疗作为脑膜旁横纹肌肉瘤颅内扩展的紧急放射治疗。我们治疗了3例诊断为脑膜旁横纹肌肉瘤延伸到颅骨的患者，这些患者在其他医院被评估为适合紧急放疗，并转移到我院进行质子束治疗。这些患者包括2名男孩和1名女孩，诊断时年龄为6至12岁，分别在诊断后第5、11和23天开始质子束治疗。脑膜旁横纹肌肉瘤延伸到颅骨的患者可以转移到配备质子束治疗的机构。为了尽量缩短开始治疗的间隔时间，一旦认识到颅内软组织肉瘤的可能性，应与有能力提供此类治疗的机构共享医疗信息。质子束治疗是颅内横纹肌肉瘤放射治疗的一种选择。
A number of cases have been reported in recent years regarding the use of proton beam therapy to mitigate adverse events affecting important cranial organs in cases of rhabdomyosarcoma at parameningeal sites. However, few reports have described the use of proton beam therapy as urgent radiotherapy for parameningeal rhabdomyosarcoma with intracranial extension. We treated 3 patients diagnosed with parameningeal rhabdomyosarcoma extending into the cranium who were assessed at other hospitals as suitable for urgent radiotherapy and transferred to our hospital for proton beam therapy. These patients comprised 2 boys and 1 girl 6 to 12 years of age at diagnosis, and proton beam therapy was started on days 5, 11, and 23 after diagnosis, respectively. Patients with parameningeal rhabdomyosarcoma extending into the cranium can be transferred to institutions equipped to perform proton beam therapy. To minimize the interval to starting therapy, medical information should be shared with institutions capable of providing such therapy as soon as the possibility of intracranial soft-tissue sarcoma is recognized. Proton beam therapy is 1 option for radiotherapy in cases of intracranial rhabdomyosarcoma.