Cell cycle abnormality in metabolic syndrome and nuclear receptors as an emerging therapeutic target.
Cell cycle abnormality in metabolic syndrome and nuclear receptors as an emerging therapeutic target.
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DOI：
10.18926/amo/50405
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发表时间：
2013
影响因子：
0.5
通讯作者：
A. Nakatsuka;J. Wada;H. Makino
中科院分区：
文献类型：
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作者：
A. Nakatsuka;J. Wada;H. Makino
近年来，许多研究人员强调了代谢综合征的重要性，因为它的患病率不断增加，而且由于相关的慢性血管并发症而导致预后不良。一组代谢和血管疾病的上游是内脏脂肪组织的积累，其在病理生理学中起着核心作用。在脂肪组织的积累中，细胞周期调节与细胞过程如增殖、肥大和凋亡紧密相关。此外，在肾脏和心血管系统等其他组织中也观察到各种细胞周期异常，它们与疾病的进展密切相关。在这里，我们讨论细胞周期异常代谢综合征在各种组织。此外，我们还描述了核受体在细胞生长和存活以及全身葡萄糖和脂质代谢中的作用。通过靶向核受体调节代谢紊乱中各种细胞周期的治疗策略可能在未来克服肥胖及其慢性血管并发症。
In recent years, many researchers have emphasized the importance of metabolic syndrome based on its increasing prevalence and its adverse prognosis due to associated chronic vascular complications. Upstream of a cluster of metabolic and vascular disorders is the accumulation of visceral adipose tissue, which plays a central role in the pathophysiology. In the accumulation of adipose tissues, cell cycle regulation is tightly linked to cellular processes such as proliferation, hypertrophy and apoptosis. In addition, various cell cycle abnormalities have also been observed in other tissues, such as kidneys and the cardiovascular system, and they are critically involved in the progression of disease. Here, we discuss cell cycle abnormalities in metabolic syndrome in various tissues. Furthermore, we describe the role of nuclear receptors in cell growth and survival, and glucose and lipid metabolism in the whole body. Therapeutic strategies for modulating various cell cycles in metabolic disorders by targeting nuclear receptors may overcome obesity and its chronic vascular complications in the future.