Role of Marine Natural Products in the Genesis of Antiviral Agents.
Role of Marine Natural Products in the Genesis of Antiviral Agents.
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DOI：
10.1021/cr4006318
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发表时间：
2015-09-23
期刊：
影响因子：
62.1
通讯作者：
Hamann MT
中科院分区：
文献类型：
--
作者：
Gogineni V;Schinazi RF;Hamann MT
哺乳动物具有复杂的生物系统，经常容易受到各种细菌、真菌、病毒和寄生虫的感染，这对不断发展的对当前药物具有抗药性的疾病株是一个重大挑战。1因此，总是需要确定针对这些生物体的新的抗感染剂。韦伯斯特将抗感染剂定义为“一种能够对抗感染、通过抑制感染剂的传播或通过直接杀死感染剂的药剂”。2一些具有研究重点的新出现和具有抗药性的传染病是人类免疫缺陷病毒(HIV)或艾滋病、乙肝和丙型肝炎病毒、呼吸道感染，如流感和呼吸道合胞病毒(RSV)，以及登革热。1图1和图2分别为我们提供了有关病毒性疾病患者死亡率和发病率的数据。3个−5
Mammals have complex biological systems and are constantly prone to infections by a wide array of bacteria, fungi, viruses, and parasites, a significant challenge to the constant development of disease-strains resistance to current drugs. 1 As a result, there is always a need to identify new anti-infective agents against these organisms. An anti-infective agent is defined by Webster as “an agent capable of acting against an infection, by inhibiting the spread of an infectious agent or by killing the infectious agent outright”. 2 Some of the emerging and drug-resistant infectious diseases having research priority are human immunodeficiency virus (HIV) or AIDS, hepatitis B and C viruses, respiratory infections such as influenza and respiratory syncytial virus (RSV), and dengue fever. 1 Figures 1 and 2 provide us with the data in regards to the mortality and incidence rates, respectively, of people with viral diseases. 3− 5