Associations between cognitive impairment and quality of life in euthymic bipolar patients
Associations between cognitive impairment and quality of life in euthymic bipolar patients
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DOI：
10.1016/j.psychres.2018.11.061
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发表时间：
2019-01-01
影响因子：
11.3
通讯作者：
Kusumi, Ichiro
中科院分区：
文献类型：
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作者：
Toyoshima, Kuniyoshi;Kako, Yuki;Kusumi, Ichiro
在双相情感障碍的正常状态下，认知功能经常受到影响。具体而言，主观和客观认知障碍可能明显影响患者的生活质量（QoL）;然而，之前未在日本患者中研究过该问题。因此，本研究调查了认知主诉、生活质量和客观认知功能之间的关系。从日本札幌的北海道大学医院招募了40例缓解期患者，并使用双相情感障碍评定量表（COBRA）中的认知主诉、医学结局研究36项简明健康调查第2版（SF-36 v2）和Sheehan残疾量表（SDS）进行评估。采用日本成人阅读量表、威斯康星州卡片分类测验、词汇流畅性、连续操作测验、连线测验（TMT）、听觉言语学习和Stroop测验评价客观认知功能。观察到COBRA、SF-36 v2和SDS结果以及TMT评分之间存在显著相关性。总体而言，情感正常的患者意识到他们的认知功能障碍，这可以理解为与他们日常生活中满意度的下降有关。因此，即使是轻微的认知障碍也会对双相情感障碍的正常状态患者产生影响。
During the euthymic state in bipolar disorder, cognitive functions often remain affected. Specifically, subjective and objective cognitive impairment might distinctly affect patients' quality of life (QoL); however, this question had not been examined previously in Japanese patients. Therefore, the current study investigated the associations between cognitive complaints, QoL, and objective cognitive functions. Forty patients in remission were recruited from the Hokkaido University Hospital, Sapporo, Japan and assessed with the translated version of the cognitive complaints in bipolar disorder rating assessment (COBRA), medical outcomes study 36-item short-form health survey version 2 (SF-36v2), and Sheehan disability scale (SDS). The Japanese adult reading scale, Wisconsin card sorting test, word fluency, continuous performance test, trail making test (TMT), auditory verbal learning, and Stroop test evaluated objective cognitive functions. Significant correlations were observed between the COBRA, SF-36v2, and SDS results, as well as the TMT scores. Overall, euthymic patients were aware of their cognitive dysfunction, which could be understood in relation to the decrease in satisfaction in their daily life. Therefore, even mild cognitive impairments can have ramifications for patients in the euthymic state of bipolar disorder.