DEGRADATION OF CHLORAMBUCIL IN AQUEOUS-SOLUTION
DEGRADATION OF CHLORAMBUCIL IN AQUEOUS-SOLUTION
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DOI：
10.1002/jps.2600690928
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发表时间：
1980-01-01
影响因子：
3.8
通讯作者：
NILSSON, SO
中科院分区：
文献类型：
--
作者：
EHRSSON, H;EKSBORG, S;NILSSON, SO
采用反相高压液相色谱法研究了苯丁酸氮芥及其降解产物4-（对-（2-氯乙基-2-羟乙基氨基）苯基）丁酸（I）的稳定性。苯丁酸氮芥的降解速率不受pH 5和10之间的pH值的影响，但在较低的pH值下降。苯丁酸氮芥和I的降解速率仅略有不同（pH > 6）。利用分光光度法和分配技术研究了化合物的蛋白水解性质。
The stability of the antineoplastic agent chlorambucil and its degradation product 4-(p-(2-chloroethyl-2-hydroxyethylamino)phenyl]butyric acid (I) was studied using reversed-phase high-pressure liquid chromatography. The degradation rate of chlorambucil was unaffected by pH between pH 5 and 10 but decreased at lower pH. The degradation rates of chlorambucil and I differed only slightly (pH > 6). The proteolytic properties of the compounds were studied using spectrophotometric and partition techniques.