Body mass index and the risk of COPD
Body mass index and the risk of COPD
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DOI：
10.1378/chest.121.2.370
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发表时间：
2002-02-01
期刊：
影响因子：
9.6
通讯作者：
Wise, RA
中科院分区：
文献类型：
--
作者：
Harik-Khan, RI;Fleg, JL;Wise, RA
背景：先前的研究已经证明了低体重对COPD患者和一般人群的预后价值。然而，目前尚不清楚低体重是否是COPD的危险因素，还是已确诊疾病的后果。研究目的：确定初始体重低的无症状受试者在随后的随访中是否有更大的COPD发展风险。设计和受试者：对巴尔的摩老龄化纵向研究中的458名男性和192名女性参与者（年龄范围，40至73岁）进行的观察性回顾性研究。在基线时，参与者没有COPD。在平均随访10.2年（男性）和6.4年（女性）后，40名男性和7名女性接受了COPD的诊断。方法：采用考克斯比例风险回归模型评估男性COPD诊断与基线体重指数（BMI）之间的关系。男性COPD发生的风险与基线BMI呈负相关，即使调整了其他风险因素，包括吸烟，年龄，FEV1预测百分比，腹部肥胖和教育状况。在男性中，最低BMI三分位数相对于最高BMI三分位数发生COPD的相对风险为2.76（95%置信区间，1.15至6.59）。少数妇女谁有COPD没有让我们得出结论，BMI作为一个危险因素COPD.Conclusion：控制混杂变量后，低BMI的男性患COPD的风险增加。
Background: Previous studies have documented the prognostic value of low body weight in patients with COPD and also in general populations. However, it is not clear whether low body weight is a risk factor for COPD or a consequence of established disease.Study objective: To determine whether asymptomatic subjects with low initial body mass were at a greater risk of having COPD develop during subsequent follow-up.Design and subjects: Observational retrospective study of 458 male and 192 female participants (age range, 40 to 73 years) in the Baltimore Longitudinal Study of Aging. At baseline, the participants did not have COPD. After mean follow-up periods of 10.2 years for the men and 6.4 years for the women, 40 men and 7 women received a diagnosis of COPD.Methods: Cox proportional-hazards regression models were used to assess the relationship between COPD diagnosis and baseline body mass index (BMI) in men.Results: The risk of COPD developing in men varied inversely with baseline BMI, even after adjusting for other risk factors, including cigarette smoking, age, FEV1 percent predicted, abdominal obesity, and educational status. In men, the relative risk of COPD developing for the lowest BMI tertile relative to the highest tertile was 2.76 (95% confidence interval, 1.15 to 6.59). The small number of women who had COPD did not allow us to draw conclusions regarding BMI as a risk factor for COPD.Conclusion:After controlling for confounding variables, men with low BMI are at increased risk for getting COPD.