Role of adipose specific lipid droplet proteins in maintaining whole body energy homeostasis.
Role of adipose specific lipid droplet proteins in maintaining whole body energy homeostasis.
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DOI：
10.1016/j.bbadis.2013.05.007
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发表时间：
2014-03
期刊：
影响因子：
--
通讯作者：
Sztalryd C
中科院分区：
文献类型：
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作者：
Konige M;Wang H;Sztalryd C
白色脂肪组织脂滴中脂质储存过量或不足与血脂异常、胰岛素抵抗和2型糖尿病风险增加有关。因此，维持脂肪脂滴的生长和功能对于保持全身胰岛素敏感性和能量稳态至关重要。在了解脂滴生物学方面的进展已经强调了与脂滴相互作用的蛋白质的作用。在这里，我们回顾了目前的知识脂肪特异性脂滴蛋白，它具有独特的功能，控制脂肪细胞的脂质储存，限制脂质溢出和脂毒作用，被认为有助于疾病。这篇文章是一个特殊问题的一部分，题为：调节脂肪组织在健康和疾病。
Excess or insufficient lipid storage in white adipose tissue lipid droplets is associated with dyslipidemia, insulin resistance and increased risk for diabetes type 2. Thus, maintenance of adipose lipid droplet growth and function is critical to preserve whole body insulin sensitivity and energy homeostasis. Progress in understanding biology of lipid droplets has underscored the role of proteins that interact with lipid droplets. Here, we review the current knowledge of adipose specific lipid droplet proteins, which share unique functions controlling adipocyte lipid storage, limiting lipid spill-over and lipotoxic effects thought to contribute to disease. This article is part of a Special Issue entitled: Modulation of Adipose Tissue in Health and Disease.