Effect of vitamin B6 deficiency on an antibody production in mice.: Part II.: Effects of vitamin B6 deficiency on cytokine levels and lymphocytes in mice
Effect of vitamin B6 deficiency on an antibody production in mice.: Part II.: Effects of vitamin B6 deficiency on cytokine levels and lymphocytes in mice
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DOI：
10.1271/bbb.62.1008
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发表时间：
1998-05-01
影响因子：
1.6
通讯作者：
Tsuge, H
中科院分区：
文献类型：
--
作者：
Doke, S;Inagaki, N;Tsuge, H
本文观察了维生素B-6（B-6）缺乏对BALB B/c小鼠细胞因子水平和淋巴细胞亚群比例的影响。未给予B-6的小鼠胸腺和脾脏中的淋巴细胞（即CD 4（+）CD 8（-）T细胞）的比例大于给予B-6的小鼠，而未给予B-6的小鼠胸腺中CD 8（+）与CD 4（+）T细胞的比例较低。在体外用伴刀豆球蛋白A刺激的脾细胞中白细胞介素-5和-10的浓度在B-6缺乏的小鼠中显著较高，其血浆皮质酮浓度也是如此。这些结果表明，B-6是必要的，以维持细胞因子水平和淋巴功能的胸腺和脾脏的小鼠。
The effects of vitamin B-6 (B-6) deficiency on cytokine levels and proportions of lymphocyte subsets in BALB/c mice were investigated. The proportion of lymphocytes from the thymus and spleen of mice given no B-6, that were CD4(+) CD8(-) T cells, was larger than in mice given B-6, and the ratio of CD8(+) to CD4(+) T cells in the thymus of mice given no B-6 was lower. The concentrations of interleukin-5 and -10 in spleen cells stimulated in vitro with concanavalin A were significantly higher in the mice with B-6 deficiency, as was their plasma corticosterone concentrations. These results suggested that B-6 is necessary to maintain cytokine levels and lymphoid function in the thymus and spleen of mice.